| Literature DB >> 25490384 |
Er Nie1, Xu Zhang2, Shao Xie2, Qiong Shi2, Jinxia Hu2, Qingming Meng2, Xiuping Zhou3, Rutong Yu4.
Abstract
Previously, we found that brain expressed X-linked gene 2 (Bex2) regulates the invasion/migration ability of glioma cells. However, the mechanism of this effect remains unknown. In current study, we reported that Bex2 down-regulation inhibited glioma cell migration and invasion by decreasing the nucleus and cytoplasm protein level of β-catenin. We found that the protein levels of Bex2 and β-catenin were up-regulated and showed direct correlation in glioma tissues. Bex2 down-regulation significantly decreased β-catenin protein levels but not its mRNA levels. Furthermore, the decreased protein level of β-catenin was located in the nucleus and cytoplasm but not in the cell membrane. Further study found that the effects of Bex2 down-regulation on the invasion and migration of glioma cell could be reversed by β-catenin over-expression. Taken together, Bex2 affects the invasion and migration ability of glioma cells by regulating β-catenin.Entities:
Keywords: Bex2; Glioblastoma; Invasion; Migration; β-Catenin
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Year: 2014 PMID： 25490384 DOI： 10.1016/j.bbrc.2014.11.113
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575