| Literature DB >> 25490242 |
Brendan M Lawson, Jarin Saktanasate, Emil Anthony T Say, Carol L Shields.
Abstract
Treatment of vitreous seeds in retinoblastoma is challenging because of relatively poor chemotherapeutic drug penetration by standard intravenous or intra-arterial routes. Intravitreal monotherapy with melphalan is effective but has a narrow therapeutic window. The authors describe a case of massive vitreous seeding successfully controlled after combination intravitreal chemotherapy using melphalan and topotecan with preserved anatomic outcome. Copyright 2014, SLACK Incorporated.Entities:
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Year: 2014 PMID： 25490242 DOI： 10.3928/01913913-20141203-05
Source DB: PubMed Journal: J Pediatr Ophthalmol Strabismus ISSN： 0191-3913 Impact factor: 1.402