Organocatalyzed asymmetric aldol reactions of ketones and β,γ-unsaturated α-ketoesters and phenylglyoxal hydrates.

Enantioselective aldol reactions of acetophenone with β,γ-unsaturated α-ketoesters and cyclic ketones with phenylglyoxal hydrates were realized with cinchona alkaloid-derived thiourea catalysts. The corresponding aldol products were obtained in high yields and good to excellent diastereoselectivities and enantioselectivities (up to 95% ee).