Literature DB >> 25489891

Potential of F-18 PET/CT in the Detection of Leptomeningeal Metastasis.

Ryan G Short1, Susan Bal2, John P German3, Raymond J Poelstra4, Arash Kardan5.   

Abstract

Leptomeningeal metastasis (LM) is a rare but increasingly common condition in which malignant cells migrate to the meninges. The gold standard for diagnosing LM is detection of cancer cells in the cerebrospinal fluid (CSF). Contrast enhanced-magnetic resonance imaging (CE-MRI) is also used to diagnose LM. We describe a case of LM in which CE-MRI of the neuroaxis was initially negative for meningeal enhancement but F-18 fluorodeoxyglucose positron-emission tomography/computed tomography (F-18 FDG PET/CT) revealed hypermetabolism within the lumbar spinal canal. Positive F-18 FDG PET findings have rarely been reported in LM and, to our knowledge, have never been reported in the context of initially negative CE-MRI scanning of the neuroaxis. F-18 FDG PET/CT may represent an alternative modality for diagnosing LM in patients who are unable to undergo CE-MRI and/or LP or in patients for whom initial CE-MRI and/or LP are negative for LM.

Entities:  

Keywords:  MR imaging; PET imaging; leptomeningeal metastasis

Mesh：

Year:  2014        PMID： 25489891      PMCID： PMC4291799          DOI： 10.15274/NRJ-2014-10098

Source DB:  PubMed          Journal:  Neuroradiol J        ISSN： 1971-4009


  16 in total

1.  The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis.

Authors:  C S Straathof; H G de Bruin; D W Dippel; C J Vecht
Journal:  J Neurol       Date:  1999-09       Impact factor: 4.849

2.  Diagnosing dural metastases: the value of 1H magnetic resonance spectroscopy.

Authors:  M Bendszus; M Warmuth-Metz; R Burger; R Klein; J C Tonn; L Solymosi
Journal:  Neuroradiology       Date:  2001-04       Impact factor: 2.804

3.  MR imaging of leptomeningeal metastases: comparison of three sequences.

Authors:  Sanjay K Singh; Norman E Leeds; Lawrence E Ginsberg
Journal:  AJNR Am J Neuroradiol       Date:  2002-05       Impact factor: 3.825

4.  Leptomeningeal carcinomatosis and intramedullary spinal cord metastases from lung cancer: detection with FDG positron emission tomography.

Authors:  T Komori; D Delbeke
Journal:  Clin Nucl Med       Date:  2001-11       Impact factor: 7.794

5.  MR imaging of the cranial meninges with emphasis on contrast enhancement and meningeal carcinomatosis.

Authors:  G Sze; S Soletsky; R Bronen; G Krol
Journal:  AJNR Am J Neuroradiol       Date:  1989 Sep-Oct       Impact factor: 3.825

6.  Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis.

Authors:  R J Freilich; G Krol; L M DeAngelis
Journal:  Ann Neurol       Date:  1995-07       Impact factor: 10.422

7.  Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma.

Authors:  Johanna C Bendell; Susan M Domchek; Harold J Burstein; Lyndsay Harris; Jerry Younger; Irene Kuter; Craig Bunnell; Montse Rue; Rebecca Gelman; Eric Winer
Journal:  Cancer       Date:  2003-06-15       Impact factor: 6.860

8.  Malignant cells in cerebrospinal fluid (CSF): the meaning of a positive CSF cytology.

Authors:  J P Glass; M Melamed; N L Chernik; J B Posner
Journal:  Neurology       Date:  1979-10       Impact factor: 9.910

9.  Screening for cerebral metastases with FDG PET in patients undergoing whole-body staging of non-central nervous system malignancy.

Authors:  Eric M Rohren; James M Provenzale; Daniel P Barboriak; R Edward Coleman
Journal:  Radiology       Date:  2003-01       Impact factor: 11.105

10.  Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients.

Authors:  W R Wasserstrom; J P Glass; J B Posner
Journal:  Cancer       Date:  1982-02-15       Impact factor: 6.860
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  7 in total

Review 1.  Diagnosis of non-osseous spinal metastatic disease: the role of PET/CT and PET/MRI.

Authors:  Ali Batouli; John Braun; Kamal Singh; Ali Gholamrezanezhad; Bethany U Casagranda; Abass Alavi
Journal:  J Neurooncol       Date:  2018-02-26       Impact factor: 4.130

2.  Extraneural Metastases in an Operated Case of Pinealoblastoma Identified on Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

Authors:  Piyush Chandra; Sneha Shah; Archi Agrawal; Nilendu Purandare; Venkatesh Rangarajan
Journal:  Indian J Nucl Med       Date:  2017 Jul-Sep

3.  "Drop" Metastases from an Operated Case of Intracranial Anaplastic Ependymoma Identified on Fluoro-2-deoxyglucose Positron Emission Tomography/Computed Tomography.

Authors:  Piyush Chandra; Nilendu Purandare; Sneha Shah; Archi Agrawal; Venkatesh Rangarajan
Journal:  Indian J Nucl Med       Date:  2017 Jan-Mar

4.  Intracranial Leptomeningeal Carcinomatosis in Three Cases from Breast Cancer Demonstrated on F-18 Fluorodeoxyglucose Positron Emission Tomography/Computerized Tomography.

Authors:  Hulya Ortapamuk; Mustafa Kemal Demir
Journal:  Indian J Nucl Med       Date:  2017 Jan-Mar

5.  Meningeal carcinomatosis: three case-reports.

Authors:  Guangyong Chen; Long Ma; Meiling Xu; Xuemei Wang; Chong Wang; Conghai Zhao; Jinnan Zhang
Journal:  World J Surg Oncol       Date:  2018-04-13       Impact factor: 2.754

6.  Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

Authors:  Susanna Nuvoli; Silvia Contu; Bi Llie Joy Pung; Patrizia Solinas; Giuseppe Madeddu; Angela Spanu
Journal:  Case Rep Neurol       Date:  2018-02-09

7.  Whole brain radiotherapy combined with intrathecal liposomal cytarabine for leptomeningeal metastasis-a safety analysis and validation of the EANO-ESMO classification.

Authors:  Sarah Iglseder; Martha Nowosielski; Gabriel Bsteh; Armin Muigg; Johanna Heugenhauser; Elke Mayer; Astrid Grams; Günther Stockhammer; Meinhard Nevinny-Stickel
Journal:  Strahlenther Onkol       Date:  2022-03-10       Impact factor: 4.033
  7 in total

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