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Literature DB >> 25489835

Taking charge of siRNA delivery.

Anastasia Khvorova¹, Maire F Osborn¹, Matthew R Hassler¹.

Abstract

Delivery of siRNA into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversible manner.

Entities: Chemical

Mesh：

Substances：

Year: 2014 PMID： 25489835 DOI： 10.1038/nbt.3091

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

7 in total

1. Synthesis of Phosphorodithioate DNA via Sulfur-Linked, Base-Labile Protecting Groups(1).

Authors: William T. Wiesler; Marvin H. Caruthers
Journal: J Org Chem Date: 1996-06-26 Impact factor: 4.354

2. Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications.

Authors: Bryan R Meade; Khirud Gogoi; Alexander S Hamil; Caroline Palm-Apergi; Arjen van den Berg; Jonathan C Hagopian; Aaron D Springer; Akiko Eguchi; Apollo D Kacsinta; Connor F Dowdy; Asaf Presente; Peter Lönn; Manuel Kaulich; Naohisa Yoshioka; Edwige Gros; Xian-Shu Cui; Steven F Dowdy
Journal: Nat Biotechnol Date: 2014-11-17 Impact factor: 54.908

3. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication.

Authors: David V Morrissey; Karin Blanchard; Lucinda Shaw; Kristi Jensen; Jennifer A Lockridge; Brent Dickinson; James A McSwiggen; Chandra Vargeese; Keith Bowman; Chris S Shaffer; Barry A Polisky; Shawn Zinnen
Journal: Hepatology Date: 2005-06 Impact factor: 17.425

Review 4. Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues.

Authors: Michael J Gait
Journal: Cell Mol Life Sci Date: 2003-05 Impact factor: 9.261

5. Cell-type specific and ligand specific enhancement of cellular uptake of oligodeoxynucleoside methylphosphonates covalently linked with a neoglycopeptide, YEE(ah-GalNAc)3.

Authors: J J Hangeland; J T Levis; Y C Lee; P O Ts'o
Journal: Bioconjug Chem Date: 1995 Nov-Dec Impact factor: 4.774

6. Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein.

Authors: Akiko Eguchi; Bryan R Meade; Yung-Chi Chang; Craig T Fredrickson; Karl Willert; Nitin Puri; Steven F Dowdy
Journal: Nat Biotechnol Date: 2009-05-17 Impact factor: 54.908

7. Tat-mediated delivery of heterologous proteins into cells.

Authors: S Fawell; J Seery; Y Daikh; C Moore; L L Chen; B Pepinsky; J Barsoum
Journal: Proc Natl Acad Sci U S A Date: 1994-01-18 Impact factor: 12.779

7 in total

1. Corrigendum: Taking charge of siRNA delivery.

Authors: Anastasia Khvorova; Maire F Osborn; Matthew R Hassler
Journal: Nat Biotechnol Date: 2015-05 Impact factor: 54.908

2. Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.

Authors: Bruno M D C Godinho; James W Gilbert; Reka A Haraszti; Andrew H Coles; Annabelle Biscans; Loic Roux; Mehran Nikan; Dimas Echeverria; Matthew Hassler; Anastasia Khvorova
Journal: Nucleic Acid Ther Date: 2017-10-12 Impact factor: 5.486

Taking charge of siRNA delivery.

1. Synthesis of Phosphorodithioate DNA via Sulfur-Linked, Base-Labile Protecting Groups(1).

2. Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications.

3. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication.

Review 4. Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues.

5. Cell-type specific and ligand specific enhancement of cellular uptake of oligodeoxynucleoside methylphosphonates covalently linked with a neoglycopeptide, YEE(ah-GalNAc)3.

6. Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein.

7. Tat-mediated delivery of heterologous proteins into cells.

1. Corrigendum: Taking charge of siRNA delivery.

2. Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.

Review 3. Transdermal delivery for gene therapy.

4. Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery.

Review 5. Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing.

Review 6. Rationale and Application of PEGylated Lipid-Based System for Advanced Target Delivery of siRNA.

7. A comparison of inverted and upright laser-activated titanium nitride micropyramids for intracellular delivery.