Literature DB >> 2548973

Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide.

S Ram1, L D Spicer.   

Abstract

Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.

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Year:  1989        PMID: 2548973     DOI: 10.1016/0883-2889(89)90207-4

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum A        ISSN: 0883-2889


  2 in total

Review 1.  11CO2 fixation: a renaissance in PET radiochemistry.

Authors:  Benjamin H Rotstein; Steven H Liang; Jason P Holland; Thomas Lee Collier; Jacob M Hooker; Alan A Wilson; Neil Vasdev
Journal:  Chem Commun (Camb)       Date:  2013-05-14       Impact factor: 6.222

2.  Silicon compounds in carbon-11 radiochemistry: present use and future perspectives.

Authors:  Federico Luzi; Antony D Gee; Salvatore Bongarzone
Journal:  Org Biomol Chem       Date:  2021-07-28       Impact factor: 3.876

  2 in total

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