Literature DB >> 25489011

Decreasing time to antibiotics in febrile patients with central lines in the emergency department.

Meghan Jobson1, Moses Sandrof2, Timothy Valeriote2, Abigail Lees Liberty3, Christine Walsh-Kelly4, Cheryl Jackson5.   

Abstract

BACKGROUND AND
OBJECTIVE: Rapid antibiotic administration is essential for the successful management of patients who have central lines and present with fever. We conducted an emergency department (ED) improvement initiative to deliver antibiotics to 90% of patients within 60 minutes and to minimize process variation.
METHODS: Our setting was an academic ED. We assembled a multidisciplinary team, identified contributing factors to the care delivery problem, determined key drivers and intervention steps, implemented changes, and used strategies to engage ED staff and promote sustainability. Outcomes were analyzed by using a time series design with baseline data and continuous postintervention monitoring. Outcomes included percentage of patients receiving antibiotics within 60 minutes, time to antibiotic administration, and accuracy for triage acuity and chief complaint.
RESULTS: An 8-month baseline period revealed that 63% of patients received antibiotics within 60 minutes of arrival, with a mean time to antibiotics of 65 minutes. Multiple Plan-Do-Study-Act (PDSA) cycles were used to improve patient identification and initial management processes. The percentage of patients receiving antibiotics within 60 minutes of arrival was increased to 99% (297 of 301), and mean time to administration decreased to 30 minutes (95% confidence interval: 28-32). These gains were sustained for 24 months. Subanalysis identified a racial discrepancy, with African American patients experiencing significantly longer delays than patients of other races (95 vs 61 minutes; P < .05); this discrepancy was eliminated with our initiative.
CONCLUSIONS: Our initiative exceeded our goal of 90% antibiotic delivery within 60 minutes for a sustained period of at least 24 months, decreased process variation and mean time to antibiotic administration, and eliminated race-based discrepancies in care.
Copyright © 2015 by the American Academy of Pediatrics.

Entities:  

Keywords:  bloodstream infection; central line; febrile neutropenia; pediatric emergency; quality improvement

Mesh:

Substances:

Year:  2014        PMID: 25489011     DOI: 10.1542/peds.2014-1192

Source DB:  PubMed          Journal:  Pediatrics        ISSN: 0031-4005            Impact factor:   7.124


  6 in total

1.  The "Golden Hour": a capacity-building initiative to decrease life-threating complications related to neutropenic fever in patients with hematologic malignancies in low- and middle-income countries.

Authors:  Mario Ornelas-Sánchez; Laura Nuño-Vázquez; Adriana Loera-Reyna; Dara Torres-Reyes; Rebeca Rivera-Gómez; Alicia Sánchez; Mitzy Romano; Miriam González; Miguela A Caniza; Paula Aristizabal
Journal:  Blood Adv       Date:  2018-11-30

Review 2.  Interventions to improve antibiotic prescribing practices for hospital inpatients.

Authors:  Peter Davey; Charis A Marwick; Claire L Scott; Esmita Charani; Kirsty McNeil; Erwin Brown; Ian M Gould; Craig R Ramsay; Susan Michie
Journal:  Cochrane Database Syst Rev       Date:  2017-02-09

3.  The Golden Hour: Sustainability and Clinical Outcomes of Adequate Time to Antibiotic Administration in Children with Cancer and Febrile Neutropenia in Northwestern Mexico.

Authors:  Miriam L Gonzalez; Paula Aristizabal; Adriana Loera-Reyna; Dara Torres; Mario Ornelas-Sánchez; Laura Nuño-Vázquez; Marco Aguilera; Alicia Sánchez; Mitzy Romano; Rebeca Rivera-Gómez; George Relyea; Paola Friedrich; Miguela A Caniza
Journal:  JCO Glob Oncol       Date:  2021-05

4.  The effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: a multicentre, cluster randomized controlled intervention study.

Authors:  Jannicke Slettli Wathne; Lars Kåre Selland Kleppe; Stig Harthug; Hege Salvesen Blix; Roy M Nilsen; Esmita Charani; Ingrid Smith
Journal:  Antimicrob Resist Infect Control       Date:  2018-09-10       Impact factor: 4.887

5.  Accelerating Initiation of Adequate Antimicrobial Therapy Using Real-Time Decision Support and Microarray Testing.

Authors:  Michael J Tchou; Heidi Andersen; Eric Robinette; Joel E Mortensen; Eleanor A Powell; Andrea Ankrum; Matthew C Washam; David B Haslam; Joshua D Courter
Journal:  Pediatr Qual Saf       Date:  2019-08-05

6.  Explanation and elaboration of the SQUIRE (Standards for Quality Improvement Reporting Excellence) Guidelines, V.2.0: examples of SQUIRE elements in the healthcare improvement literature.

Authors:  Daisy Goodman; Greg Ogrinc; Louise Davies; G Ross Baker; Jane Barnsteiner; Tina C Foster; Kari Gali; Joanne Hilden; Leora Horwitz; Heather C Kaplan; Jerome Leis; John C Matulis; Susan Michie; Rebecca Miltner; Julia Neily; William A Nelson; Matthew Niedner; Brant Oliver; Lori Rutman; Richard Thomson; Johan Thor
Journal:  BMJ Qual Saf       Date:  2016-04-13       Impact factor: 7.035

  6 in total

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