Achille Tarsitano1, Maria Lucia Tardio2, Claudio Marchetti3. 1. Researcher, Department of Biomedical and Neuromotorial Science, University of Bologna, Maxillofacial Surgery Unit, Policlinico S. Orsola-Malpighi Hospital, Bologna, Italy. Electronic address: Achilletarsitano@gmail.com. 2. Medical Doctor, Section of Pathology, S. Orsola-Malpighi Hospital, Bologna, Italy. 3. Professor of Maxillofacial Surgery, Department of Biomedical and Neuromotorial Science, University of Bologna, Maxillofacial Surgery Unit, Policlinico S. Orsola-Malpighi Hospital, Bologna, Italy.
Abstract
OBJECTIVE: Perineural invasion (PNI) is frequent in oral squamous cell carcinoma (OSCC) and could play an important role in treatment decisions. STUDY DESIGN: This retrospective study used multivariate analysis to evaluate the impact of PNI on locoregional recurrence, neck metastases, and survival in 236 consecutive patients with oral cancer. RESULTS: There were significant differences in the local (P = .007) and regional (P = .041) failure rates in the PNI-positive group compared with the PNI-negative group. Univariate analysis demonstrated that PNI-positive patients had significantly worse locoregional control (P = .011), disease-specific survival (P = .023), and overall survival (P = .046) compared with PNI-negative patients. CONCLUSION: PNI was an independent predictor of local and regional failure in a well-defined, homogeneous population with OSCC.
OBJECTIVE: Perineural invasion (PNI) is frequent in oral squamous cell carcinoma (OSCC) and could play an important role in treatment decisions. STUDY DESIGN: This retrospective study used multivariate analysis to evaluate the impact of PNI on locoregional recurrence, neck metastases, and survival in 236 consecutive patients with oral cancer. RESULTS: There were significant differences in the local (P = .007) and regional (P = .041) failure rates in the PNI-positive group compared with the PNI-negative group. Univariate analysis demonstrated that PNI-positive patients had significantly worse locoregional control (P = .011), disease-specific survival (P = .023), and overall survival (P = .046) compared with PNI-negative patients. CONCLUSION: PNI was an independent predictor of local and regional failure in a well-defined, homogeneous population with OSCC.
Authors: Ligia B Schmitd; Cindy Perez-Pacheco; Emily L Bellile; Weisheng Wu; Keith Casper; Michelle Mierzwa; Laura S Rozek; Gregory T Wolf; Jeremy M G Taylor; Nisha J D'Silva Journal: Clin Cancer Res Date: 2022-08-15 Impact factor: 13.801
Authors: Muzafar A Macha; Nissar A Wani; Rais A Ganai; Ajaz A Bhat; Abid Hamid; Sheema Hashem; Mohammad Haris; Sham S Chauhan; Mohammad A Zargar; Surinder K Batra Journal: Adv Exp Med Biol Date: 2020 Impact factor: 2.622