Literature DB >> 25487308

Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata.

Nguyen Tuan Hiep1, Jaeyoung Kwon1, Dong-Woo Kim2, Bang Yeon Hwang3, Hak-Ju Lee4, Woongchon Mar5, Dongho Lee6.   

Abstract

Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  6-OHDA; Cudrania tricuspidata; Human neuroblastoma SH-SY5Y; Isoflavones; Moraceae; Neuroprotection; Parkinson’s disease

Mesh：

Substances：

Year:  2014        PMID： 25487308     DOI： 10.1016/j.phytochem.2014.10.021

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  9 in total

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2.  Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis.

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4.  Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata.

Authors:  Nguyen Tuan Hiep; Jaeyoung Kwon; Sungeun Hong; Nahyun Kim; Yuanqiang Guo; Bang Yeon Hwang; Woongchon Mar; Dongho Lee
Journal:  Sci Rep       Date:  2019-02-11       Impact factor: 4.379

5.  Neuroprotective Effect of Cudrania tricuspidata Fruit Extracts on Scopolamine-Induced Learning and Memory Impairment.

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7.  Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts.

Authors:  Seung-Hui Song; Sung Hwan Ki; Dae-Hun Park; Hong-Seop Moon; Chang-Dai Lee; In-Soo Yoon; Seung-Sik Cho
Journal:  Molecules       Date:  2017-09-07       Impact factor: 4.411

8.  Tyrosinase Inhibition Antioxidant Effect and Cytotoxicity Studies of the Extracts of Cudrania tricuspidata Fruit Standardized in Chlorogenic Acid.

Authors:  Ha-Na Oh; Dae-Hun Park; Ji-Yeon Park; Seung-Yub Song; Sung-Ho Lee; Goo Yoon; Hong-Seop Moon; Deuk-Sil Oh; Sang-Hoon Rhee; Eun-Ok Im; In-Soo Yoon; Jung-Hyun Shim; Seung-Sik Cho
Journal:  Molecules       Date:  2019-09-07       Impact factor: 4.411

9.  Efficacy of Alpinumisoflavone Isolated from Maclura tricuspidata Fruit in Tumor Necrosis Factor-α-Induced Damage of Human Dermal Fibroblasts.

Authors:  Sullim Lee; Giang Do Hoang; Daeyoung Kim; Ho Sueb Song; Sungyoul Choi; Dongho Lee; Ki Sung Kang
Journal:  Antioxidants (Basel)       Date:  2021-03-25
  9 in total

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