| Literature DB >> 25486950 |
Nina Shah1, Katy Rezvani2, Chitra Hosing2, Partow Kebriaei2, William Wierda3, Laurence Cooper4, Elizabeth Shpall2.
Abstract
Over the past several years there has been considerable progress in the number and breadth of therapeutic options for patients with chronic lymphocytic leukemia. In particular, cumulative experience with stem cell transplant and immunotherapy has made these modalities more available to a broader range of patients. Advances in genetic engineering and ex vivo expansion techniques have sculpted cellular therapy products to optimize the combination of specificity and toxicity. This brief review discusses recent cutting-edge experience with chimeric antigen receptor T cells as well as developing cellular therapy products at the authors' institution.Entities:
Keywords: Chimeric antigen receptors; Immunotherapy; NK cells; Stem cell transplant; T cells
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Year: 2014 PMID: 25486950 PMCID: PMC4844462 DOI: 10.1016/j.clml.2014.06.013
Source DB: PubMed Journal: Clin Lymphoma Myeloma Leuk ISSN: 2152-2669