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Literature DB >> 2548634

Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner.

Abstract

Tail currents through Na+ channels have been measured in inside-out patches from Xenopus laevis oocytes injected with cDNA-derived mRNA coding for the rat brain type II Na+ channel. It is shown that intracellular Mg2+ blocks outward currents in a voltage- and dose-dependent manner with a half blocking concentration between 3 and 4 mM at 0 mV and a voltage dependence of e-fold per 49 mV.

Entities: Chemical Species

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Year: 1989 PMID： 2548634 PMCID： PMC1330591 DOI： 10.1016/S0006-3495(89)82922-4

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

16 in total

1. Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes.

Authors: R E White; H C Hartzell
Journal: Science Date: 1988-02-12 Impact factor: 47.728

2. Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells.

Authors: H Matsuda
Journal: J Physiol Date: 1988-03 Impact factor: 5.182

3. Rectification of muscarinic K+ current by magnesium ion in guinea pig atrial cells.

Authors: M Horie; H Irisawa
Journal: Am J Physiol Date: 1987-07

4. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors: O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal: Pflugers Arch Date: 1981-08 Impact factor: 3.657

5. Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres.

Authors: P A Pappone
Journal: J Physiol Date: 1980-09 Impact factor: 5.182

6. Sodium channel permeation in squid axons. I: Reversal potential experiments.

Authors: T B Begenisich; M D Cahalan
Journal: J Physiol Date: 1980-10 Impact factor: 5.182

7. Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations.

Authors: T B Begenisich; M D Cahalan
Journal: J Physiol Date: 1980-10 Impact factor: 5.182

8. Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106.

Authors: B Nilius
Journal: J Physiol Date: 1988-05 Impact factor: 5.182

9. Patch clamp characterization of sodium channels expressed from rat brain cDNA.

Authors: W Stühmer; C Methfessel; B Sakmann; M Noda; S Numa
Journal: Eur Biophys J Date: 1987 Impact factor: 1.733

10. Inactivation of the sodium channel. I. Sodium current experiments.

Authors: F Bezanilla; C M Armstrong
Journal: J Gen Physiol Date: 1977-11 Impact factor: 4.086

19 in total

1. Variable ratio of permeability to gating charge of rBIIA sodium channels and sodium influx in Xenopus oocytes.

Authors: N G Greeff; F J Kühn
Journal: Biophys J Date: 2000-11 Impact factor: 4.033

2. A macro cell-attached patch-clamp study of the properties of the Na current in the vicinity of the motor endplate region of frog single interosseal skeletal muscle fibres.

Authors: C O Malécot; A Duval
Journal: Pflugers Arch Date: 1992-03 Impact factor: 3.657

Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner.

1. Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes.

2. Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells.

3. Rectification of muscarinic K+ current by magnesium ion in guinea pig atrial cells.

4. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

5. Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres.

6. Sodium channel permeation in squid axons. I: Reversal potential experiments.

7. Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations.

8. Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106.

9. Patch clamp characterization of sodium channels expressed from rat brain cDNA.

10. Inactivation of the sodium channel. I. Sodium current experiments.

1. Variable ratio of permeability to gating charge of rBIIA sodium channels and sodium influx in Xenopus oocytes.

2. A macro cell-attached patch-clamp study of the properties of the Na current in the vicinity of the motor endplate region of frog single interosseal skeletal muscle fibres.

3. Effects of intracellular magnesium on Kv1.5 and Kv2.1 potassium channels.

4. Voltage-dependent block by intracellular Mg2+ of N-methyl-D-aspartate-activated channels.

5. Competitive blockage of the sodium channel by intracellular magnesium ions in central mammalian neurones.

6. Properties of a potassium-selective ion channel in human melanoma cells.

7. Voltage clamp of the cardiac sodium current at 37 degrees C in physiologic solutions.

8. Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating.

9. Modulation of single cardiac Na+ channels by cytosolic Mg++ ions.

10. Use dependence of tetrodotoxin block of sodium channels: a revival of the trapped-ion mechanism.