Literature DB >> 25486189

Neurodegeneration in Huntington's disease involves loss of cystathionine γ-lyase.

Bindu D Paul1, Solomon H Snyder.   

Abstract

Entities:  

Keywords:  CO, carbon monoxide; HD, Huntington's disease; Keap1, Kelch-like ECH-associated protein 1; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; Rhes; TAF4, TBP associated factor 4; TBP, TATA box binding protein; corpus striatum; cystathionine γ-lyase; cysteine; hydrogen sulfide; specificity protein-1 (SP1)

Mesh：

Substances：

Year:  2014        PMID： 25486189      PMCID： PMC4614824          DOI： 10.4161/15384101.2014.950538

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  10 in total

1.  Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity.

Authors:  Srinivasa Subramaniam; Katherine M Sixt; Roxanne Barrow; Solomon H Snyder
Journal:  Science       Date:  2009-06-05       Impact factor: 47.728

2.  Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine.

Authors:  Marcela V Karpuj; Mark W Becher; Joe E Springer; Dorothee Chabas; Sawsan Youssef; Rosetta Pedotti; Dennis Mitchell; Lawrence Steinman
Journal:  Nat Med       Date:  2002-02       Impact factor: 53.440

3.  Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease.

Authors:  Bindu D Paul; Juan I Sbodio; Risheng Xu; M Scott Vandiver; Jiyoung Y Cha; Adele M Snowman; Solomon H Snyder
Journal:  Nature       Date:  2014-03-26       Impact factor: 49.962

Review 4.  H₂S signalling through protein sulfhydration and beyond.

Authors:  Bindu D Paul; Solomon H Snyder
Journal:  Nat Rev Mol Cell Biol       Date:  2012-07-11       Impact factor: 94.444

5.  Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation.

Authors:  Jonathan H Fox; David S Barber; Bhupinder Singh; Birgit Zucker; Mary K Swindell; Fran Norflus; Rodica Buzescu; Raman Chopra; Robert J Ferrante; Aleksey Kazantsev; Steven M Hersch
Journal:  J Neurochem       Date:  2004-10       Impact factor: 5.372

6.  H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.

Authors:  Guangdong Yang; Lingyun Wu; Bo Jiang; Wei Yang; Jiansong Qi; Kun Cao; Qinghe Meng; Asif K Mustafa; Weitong Mu; Shengming Zhang; Solomon H Snyder; Rui Wang
Journal:  Science       Date:  2008-10-24       Impact factor: 47.728

7.  Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.

Authors:  Guangdong Yang; Kexin Zhao; Youngjun Ju; Sarathi Mani; Qiuhui Cao; Stephanie Puukila; Neelam Khaper; Lingyun Wu; Rui Wang
Journal:  Antioxid Redox Signal       Date:  2013-02-07       Impact factor: 8.401

8.  Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression.

Authors:  Isao Ishii; Noriyuki Akahoshi; Xiao-Nian Yu; Yuriko Kobayashi; Kazuhiko Namekata; Gen Komaki; Hideo Kimura
Journal:  Biochem J       Date:  2004-07-01       Impact factor: 3.857

9.  Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.

Authors:  F Trettel; D Rigamonti; P Hilditch-Maguire; V C Wheeler; A H Sharp; F Persichetti; E Cattaneo; M E MacDonald
Journal:  Hum Mol Genet       Date:  2000-11-22       Impact factor: 6.150

10.  Sulfhydration mediates neuroprotective actions of parkin.

Authors:  M Scott Vandiver; Bindu D Paul; Risheng Xu; Senthilkumar Karuppagounder; Feng Rao; Adele M Snowman; Han Seok Ko; Yun Il Lee; Valina L Dawson; Ted M Dawson; Nilkantha Sen; Solomon H Snyder
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  10 in total
  17 in total

1.  Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington's disease.

Authors:  Juan I Sbodio; Solomon H Snyder; Bindu D Paul
Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-09       Impact factor: 11.205

2.  Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.

Authors:  Qing Ouyang; Tojo Nakayama; Ozan Baytas; Shawn M Davidson; Chendong Yang; Michael Schmidt; Sofia B Lizarraga; Sasmita Mishra; Malak Ei-Quessny; Saima Niaz; Mirrat Gul Butt; Syed Imran Murtaza; Afzal Javed; Haroon Rashid Chaudhry; Dylan J Vaughan; R Sean Hill; Jennifer N Partlow; Seung-Yun Yoo; Anh-Thu N Lam; Ramzi Nasir; Muna Al-Saffar; A James Barkovich; Matthew Schwede; Shailender Nagpal; Anna Rajab; Ralph J DeBerardinis; David E Housman; Ganeshwaran H Mochida; Eric M Morrow
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-06       Impact factor: 11.205

Review 3.  H2S: A Novel Gasotransmitter that Signals by Sulfhydration.

Authors:  Bindu D Paul; Solomon H Snyder
Journal:  Trends Biochem Sci       Date:  2015-10-01       Impact factor: 13.807

4.  Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Authors:  Renee R Handley; Suzanne J Reid; Rudiger Brauning; Paul Maclean; Emily R Mears; Imche Fourie; Stefano Patassini; Garth J S Cooper; Skye R Rudiger; Clive J McLaughlan; Paul J Verma; James F Gusella; Marcy E MacDonald; Henry J Waldvogel; C Simon Bawden; Richard L M Faull; Russell G Snell
Journal:  Proc Natl Acad Sci U S A       Date:  2017-12-11       Impact factor: 11.205

5.  A Cell Trappable Methyl Rhodol-Based Fluorescent Probe for Hydrogen Sulfide Detection.

Authors:  Kaylin G Fosnacht; Matthew D Hammers; Mary S Earp; Annie K Gilbert; Michael D Pluth
Journal:  Chem Asian J       Date:  2022-07-08

Review 6.  Regulators of the transsulfuration pathway.

Authors:  Juan I Sbodio; Solomon H Snyder; Bindu D Paul
Journal:  Br J Pharmacol       Date:  2018-08-23       Impact factor: 8.739

Review 7.  Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities.

Authors:  Juan I Sbodio; Solomon H Snyder; Bindu D Paul
Journal:  Antioxid Redox Signal       Date:  2018-05-04       Impact factor: 8.401

8.  Cystathionine Levels in Patients With Huntington Disease.

Authors:  N A Aziz; W Onkenhout; H J Kerstens; Raymund A C Roos
Journal:  PLoS Curr       Date:  2015-09-16

9.  Identification of Proteins Interacting with Cytoplasmic High-Mobility Group Box 1 during the Hepatocellular Response to Ischemia Reperfusion Injury.

Authors:  Tianjiao Zhang; Weiwei Wei; Olaf Dirsch; Thomas Krüger; Chunyi Kan; Chichi Xie; Olaf Kniemeyer; Haoshu Fang; Utz Settmacher; Uta Dahmen
Journal:  Int J Mol Sci       Date:  2017-01-16       Impact factor: 5.923

Review 10.  Fluorescein Based Fluorescence Sensors for the Selective Sensing of Various Analytes.

Authors:  Keerthana S; Bincy Sam; Louis George; Sudhakar Y N; Anitha Varghese
Journal:  J Fluoresc       Date:  2021-07-13       Impact factor: 2.217
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