Literature DB >> 2548480

Platelet-derived-growth-factor-stimulated heterogeneous polyphosphoinositide metabolism and phosphate uptake in C3H fibroblasts.

H Holmsen1, R Male, S Rongved, N Langeland, J Lillehaug.   

Abstract

Pig platelet-derived growth factor (PDGF) increased the rate of [32P]Pi uptake by murine fibroblasts, resulting in a 3-9-fold elevation of the specific radioactivity of ATP, PtdInsP, PtdInsP2, PtdIns and phosphatidic acid. The specific radioactivity was 10-60-fold higher in ATP than in the four phospholipids. These substances are therefore not in metabolic equilibrium, which complicates determination of inositol phospholipid turnover.

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Year:  1989        PMID： 2548480      PMCID： PMC1138709          DOI： 10.1042/bj2600589

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

1.  Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate.

Authors:  C E King; L R Stephens; P T Hawkins; G R Guy; R H Michell
Journal:  Biochem J       Date:  1987-05-15       Impact factor: 3.857

2.  Stimulation of phosphate uptake in human platelets by thrombin and collagen. Changes in specific 32P labeling of metabolic ATP and polyphosphoinositides.

Authors:  A J Verhoeven; O B Tysnes; O Horvli; C A Cook; H Holmsen
Journal:  J Biol Chem       Date:  1987-05-25       Impact factor: 5.157

3.  Regulation of phosphoinositide phosphorylation in Swiss 3T3 cells stimulated by platelet-derived growth factor.

Authors:  M L MacDonald; K F Mack; J A Glomset
Journal:  J Biol Chem       Date:  1987-01-25       Impact factor: 5.157

4.  Synergism between thrombin and epinephrine in human platelets: different dose-response relationships for aggregation and dense granule secretion.

Authors:  V M Steen; H Holmsen
Journal:  Thromb Haemost       Date:  1985-10-30       Impact factor: 5.249

5.  Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets.

Authors:  A J Verhoeven; O B Tysnes; G M Aarbakke; C A Cook; H Holmsen
Journal:  Eur J Biochem       Date:  1987-07-01

6.  Polyphosphoinositide metabolism in baby-hamster kidney cells infected with herpes simplex virus type 1.

Authors:  N Langeland; L Haarr; H Holmsen
Journal:  Biochem J       Date:  1986-08-01       Impact factor: 3.857

7.  Turnover of phosphomonoester groups and compartmentation of polyphosphoinositides in human erythrocytes.

Authors:  E Müller; H Hegewald; K Jaroszewicz; G A Cumme; H Hoppe; H Frunder
Journal:  Biochem J       Date:  1986-05-01       Impact factor: 3.857

8.  Effects of PDGF on inositol phosphates, Ca2+, and contraction of mesangial cells.

Authors:  P Menè; H E Abboud; G R Dubyak; A Scarpa; M J Dunn
Journal:  Am J Physiol       Date:  1987-09

9.  Transport changes rapidly initiated by serum addition to "contact inhibited" 3T3 cells.

Authors:  D D Cunningham; A B Pardee
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205

10.  Elevation of cAMP in cultured mesangial cells diminishes vasopressin-stimulated increases of phosphate uptake and 32P-specific activity in ATP but has no effect on phosphoinositide metabolism.

Authors:  D A Troyer; O F Gonzalez; M A Venkatachalam; J I Kreisberg
Journal:  J Biol Chem       Date:  1987-02-05       Impact factor: 5.157
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  1 in total

1.  Choline derived from the phosphatidylcholine specific phospholipase D is not directly available for the CDP choline pathway in phorbol ester-treated C3H10T1/2 Cl 8 fibroblasts.

Authors:  V A Thorsen; O Bruland; J R Lillehaug; H Holmsen
Journal:  Mol Cell Biochem       Date:  1998-10       Impact factor: 3.396
  1 in total

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