Author's Reply.

Sir,

We appreciate the interest shown by Picollo V, Russo T, Ruocco E and Baroni A[1] in our article on “Psoriasis sparing the polio affected limb: Is it merely the Koebner phenomenon?”.[2] According to them, our hypothesis that friction and increased weight bearing on the polio-non-affected right lower limb may be the reasons for the preponderance of lesions on that limb is not thoroughly convincing. While agreeing with their view, we have in fact clearly conceded in our article that we could not get any other plausible explanation to clearly explain this finding clearly. However we cannot but disagree with their other suggestion that immune alterations and resultant possible neuropeptide alterations after an injury may have a role in this case. Very important thing all of us have to note here is that the neuropeptides around which this entire discussion is revolving including that of immune alterations and immune compromised cutaneous district is not at all relevant in our case. Because even though neurogenic factors are no doubt involved in psoriasis pathogenesis, they are not considered in our case as they are reported to be relevant only in diseases with sensory impairment. Sensory impairment is not a feature of Polio. We have made this very clear in our article itself. We once again thank Picollo V, Russo T, Ruocco E and Baroni A for their interest in our article and their valuable inputs.