Dhruvinkumar Patel1, Kurtis T James2, Martin O'Toole3, Guandong Zhang4, Robert S Keynton5, André M Gobin6. 1. Department of Bioengineering, University of Louisville, Louisville, KY 40292, United States. Electronic address: dnpatel01@gmail.com. 2. Department of Bioengineering, University of Louisville, Louisville, KY 40292, United States. Electronic address: kurtis.james@louisville.edu. 3. Department of Bioengineering, University of Louisville, Louisville, KY 40292, United States. Electronic address: martin.otoole@louisville.edu. 4. Department of Bioengineering, University of Louisville, Louisville, KY 40292, United States. Electronic address: guandongzhang@hotmail.com. 5. Department of Bioengineering, University of Louisville, Louisville, KY 40292, United States. Electronic address: rob.keynton@louisville.edu. 6. Department of Bioengineering, University of Louisville, Louisville, KY 40292, United States. Electronic address: iamgobin@gmail.com.
Abstract
HYPOTHESIS: A facile, dialysis-based synthesis of stable near infrared (nIR) absorbing plasmonic gold nanoparticles (λmax=650-1000 nm) will increase the yield of nIR particles and reduce the amount of gold colloid contaminant in the product mixture. EXPERIMENTS: Chloroauric acid and sodium thiosulfate were reacted using a dialysis membrane as a reaction vessel. Product yield and composition was determined and compared to traditional synthesis methods. The product particle distribution, yield, and partitioning of gold between dispersed product and membrane-adsorbed gold were determined. FINDINGS: The synthesis results in polydisperse particle suspensions comprised of 70% spheroid-like particles, 27% triangular plates, and 3% rod-like structures with a 3% batch-to-batch variation and a prominent nIR absorption band with λmax=650-1000 nm. The amount of small gold colloid (λmax=530 nm; d<10 nm) in the isolated product was reduced by 96% compared to traditional methods. Additionally, 91.1% of the gold starting material is retained in the solution-based nanoparticle mixture while 8.2% is found on the dialysis membrane. The synthesis results in a quality ratio (QR=Abs(nIR)/Abs(530)) of 1.7-2.4 (twice that of previous techniques) and 14.3 times greater OD∗ml yield of the nIR-absorbing nanoparticle fraction.
HYPOTHESIS: A facile, dialysis-based synthesis of stable near infrared (nIR) absorbing plasmonic gold nanoparticles (λmax=650-1000 nm) will increase the yield of nIR particles and reduce the amount of gold colloid contaminant in the product mixture. EXPERIMENTS: Chloroauric acid and sodium thiosulfate were reacted using a dialysis membrane as a reaction vessel. Product yield and composition was determined and compared to traditional synthesis methods. The product particle distribution, yield, and partitioning of gold between dispersed product and membrane-adsorbed gold were determined. FINDINGS: The synthesis results in polydisperse particle suspensions comprised of 70% spheroid-like particles, 27% triangular plates, and 3% rod-like structures with a 3% batch-to-batch variation and a prominent nIR absorption band with λmax=650-1000 nm. The amount of small gold colloid (λmax=530 nm; d<10 nm) in the isolated product was reduced by 96% compared to traditional methods. Additionally, 91.1% of the gold starting material is retained in the solution-based nanoparticle mixture while 8.2% is found on the dialysis membrane. The synthesis results in a quality ratio (QR=Abs(nIR)/Abs(530)) of 1.7-2.4 (twice that of previous techniques) and 14.3 times greater OD∗ml yield of the nIR-absorbing nanoparticle fraction.
Authors: Scott-Eugene Saverot; Laura M Reese; Daniela Cimini; Peter J Vikesland; Lissett Ramirez Bickford Journal: Nanoscale Res Lett Date: 2015-05-28 Impact factor: 4.703