Literature DB >> 2548415

Intrathecal clonidine suppresses noxiously evoked activity of spinal wide dynamic range neurons in cats.

K Murata1, I Nakagawa, Y Kumeta, L M Kitahata, J G Collins.   

Abstract

The analgesic effectiveness of perispinal clonidine administration prompted us to evaluate clonidine effects on spinal dorsal horn wide dynamic range neurons. Intrathecal clonidine produced a dose-dependent (10 and 30 micrograms), yohimbine-reversible suppression of noxiously evoked activity in decerebrate, spinal cord-transected cats. In addition, combining ineffective intrathecal doses of morphine (25 micrograms) and clonidine (5 micrograms) produced statistically significant, reversible suppression of noxiously evoked activity. The time course of suppression was similar to that observed behaviorally. These results support the role of spinal alpha 2-adrenergic receptors in clonidine analgesia.

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Year:  1989        PMID： 2548415

Source DB:  PubMed          Journal:  Anesth Analg        ISSN： 0003-2999            Impact factor:   5.108


  6 in total

1.  Systemic clonidine activates neurons of the dorsal horn, but not the locus ceruleus (A6) or the A7 area, after a formalin test: the importance of the dorsal horn in the antinociceptive effects of clonidine.

Authors:  Taeko Fukuda; Hajime Furukawa; Setsuji Hisano; Hidenori Toyooka
Journal:  J Anesth       Date:  2006       Impact factor: 2.078

2.  The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats.

Authors:  Hyun Jung Kim; Tae Kyung Seol; Hee Jong Lee; Tony L Yaksh; Jong Hun Jun
Journal:  J Anesth       Date:  2011-10-09       Impact factor: 2.078

3.  alpha-Adrenoceptor and opioid receptor modulation of clonidine-induced antinociception.

Authors:  F Sierralta; D Naquira; G Pinardi; H F Miranda
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

4.  The spinal antinociceptive activity of the alpha 2-adrenoceptor agonist, xylazine in sheep.

Authors:  A E Kyles; A E Waterman; A Livingston
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

5.  [Antinociceptive effects of alpha(2)-adrenoceptor agonists ("analgesic" actions in animal experiments)agonists ("analgesic" actions in animal experiments).].

Authors:  I Jurna
Journal:  Schmerz       Date:  1995-11       Impact factor: 1.107

Review 6.  Pain pathways and transmission.

Authors:  L M Kitahata
Journal:  Yale J Biol Med       Date:  1993 Sep-Oct
  6 in total

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