Literature DB >> 25483183

Cancer therapy. Targeting the poison within.

Veronique A J Smits1, David A Gillespie.   

Abstract

Keywords:  DNA damage; DNA repair; MTH1; cancer therapy; oxidative stress

Mesh：

Substances：

Year:  2014        PMID： 25483183      PMCID： PMC4128877          DOI： 10.4161/cc.29756

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  16 in total

1.  Analysis of MTH1 gene function in mice with targeted mutagenesis.

Authors:  T Tsuzuki; A Egashira; S Kura
Journal:  Mutat Res       Date:  2001-06-02       Impact factor: 2.433

2.  Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence.

Authors:  P Rai; J J Young; D G A Burton; M G Giribaldi; T T Onder; R A Weinberg
Journal:  Oncogene       Date:  2010-11-15       Impact factor: 9.867

Review 3.  "Targeting the absence" and therapeutic engineering for cancer therapy.

Authors:  Mikhail V Blagosklonny
Journal:  Cell Cycle       Date:  2008-05-08       Impact factor: 4.534

4.  SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway.

Authors:  A B Walsh; M Dhanasekaran; D Bar-Sagi; C C Kumar
Journal:  Oncogene       Date:  1997-11-20       Impact factor: 9.867

5.  Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patients.

Authors:  Elzbieta Speina; Katarzyna D Arczewska; Daniel Gackowski; Maja Zielińska; Agnieszka Siomek; Janusz Kowalewski; Ryszard Oliński; Barbara Tudek; Jaroslaw T Kuśmierek
Journal:  J Natl Cancer Inst       Date:  2005-03-02       Impact factor: 13.506

6.  Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer.

Authors:  K Okamoto; S Toyokuni; W J Kim; O Ogawa; Y Kakehi; S Arao; H Hiai; O Yoshida
Journal:  Int J Cancer       Date:  1996-02-08       Impact factor: 7.396

7.  Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells.

Authors:  C H Kennedy; R Cueto; S A Belinsky; J F Lechner; W A Pryor
Journal:  FEBS Lett       Date:  1998-06-05       Impact factor: 4.124

Review 8.  Hallmarks of 'BRCAness' in sporadic cancers.

Authors:  Nicholas Turner; Andrew Tutt; Alan Ashworth
Journal:  Nat Rev Cancer       Date:  2004-10       Impact factor: 60.716

9.  Targeting autophagy addiction in cancer.

Authors:  Joseph D Mancias; Alec C Kimmelman
Journal:  Oncotarget       Date:  2011-12

10.  Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.

Authors:  Hannah Farmer; Nuala McCabe; Christopher J Lord; Andrew N J Tutt; Damian A Johnson; Tobias B Richardson; Manuela Santarosa; Krystyna J Dillon; Ian Hickson; Charlotte Knights; Niall M B Martin; Stephen P Jackson; Graeme C M Smith; Alan Ashworth
Journal:  Nature       Date:  2005-04-14       Impact factor: 69.504
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  4 in total

1.  Sumoylation regulates EXO1 stability and processing of DNA damage.

Authors:  Serena Bologna; Veronika Altmannova; Emanuele Valtorta; Christiane Koenig; Prisca Liberali; Christian Gentili; Dorothea Anrather; Gustav Ammerer; Lucas Pelkmans; Lumir Krejci; Stefano Ferrari
Journal:  Cell Cycle       Date:  2015-06-17       Impact factor: 4.534

2.  Potent and specific MTH1 inhibitors targeting gastric cancer.

Authors:  Wenjuan Zhou; Liying Ma; Jing Yang; Hui Qiao; Lingyu Li; Qian Guo; Jinlian Ma; Lijuan Zhao; Junwei Wang; Guozhong Jiang; Xiangbin Wan; Mariusz Adam Goscinski; Lina Ding; Yichao Zheng; Wencai Li; Hongmin Liu; Zhenhe Suo; Wen Zhao
Journal:  Cell Death Dis       Date:  2019-06-04       Impact factor: 8.469

3.  Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures.

Authors:  Lizet M van der Waals; Jamila Laoukili; Jennifer M J Jongen; Danielle A Raats; Inne H M Borel Rinkes; Onno Kranenburg
Journal:  Sci Rep       Date:  2019-01-28       Impact factor: 4.379

Review 4.  In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery.

Authors:  Lauro Ribeiro de Souza Neto; José Teófilo Moreira-Filho; Bruno Junior Neves; Rocío Lucía Beatriz Riveros Maidana; Ana Carolina Ramos Guimarães; Nicholas Furnham; Carolina Horta Andrade; Floriano Paes Silva
Journal:  Front Chem       Date:  2020-02-18       Impact factor: 5.221
  4 in total

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