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Literature DB >> 25483074

HMGA1-pseudogene overexpression contributes to cancer progression.

Francesco Esposito¹, Marco De Martino, Floriana Forzati, Alfredo Fusco.

Abstract

Two pseudogenes for HMGA1, whose overexpression has a critical role in cancer progression, have been identified. They act as decoy for miRNAs that are able to target the HMGA1 gene then enhancing cell proliferation and migration. Moreover, these pseudogenes contain sequences that are potential target sites for cancer-related miRNAs. Interestingly, HMGA1 pseudogenes are highly expressed in human anaplastic thyroid carcinomas, that is one of the most aggressive tumor in mankind, but almost undetectable in well differentiated thyroid carcinomas.

Entities: Disease Gene Species

Mesh：

Substances：
HMGA Proteins
MicroRNAs

Year: 2014 PMID： 25483074 PMCID： PMC4613653 DOI： 10.4161/15384101.2014.974440

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

27 in total

1. HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma.

Authors: Salvatore Piscuoglio; Inti Zlobec; Pierlorenzo Pallante; Romina Sepe; Francesco Esposito; Arthur Zimmermann; Ioannis Diamantis; Luigi Terracciano; Alfredo Fusco; Eva Karamitopoulou
Journal: Histopathology Date: 2012-02 Impact factor: 5.087

2. Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2.

Authors: Francesco Esposito; Mara Tornincasa; Pierlorenzo Pallante; Antonella Federico; Eleonora Borbone; Giovanna Maria Pierantoni; Alfredo Fusco
Journal: J Clin Endocrinol Metab Date: 2012-03-07 Impact factor: 5.958

3. PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.

Authors: Dario Palmieri; Teresa Valentino; Ivana De Martino; Francesco Esposito; Paolo Cappabianca; Anne Wierinckx; Michela Vitiello; Gaetano Lombardi; Annamaria Colao; Jacqueline Trouillas; Giovanna Maria Pierantoni; Alfredo Fusco; Monica Fedele
Journal: Endocr Relat Cancer Date: 2012-04-10 Impact factor: 5.678

4. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.

Authors: Zhengdong D Zhang; Adam Frankish; Toby Hunt; Jennifer Harrow; Mark Gerstein
Journal: Genome Biol Date: 2010-03-08 Impact factor: 13.583

Review 5. Roles of HMGA proteins in cancer.

Authors: Alfredo Fusco; Monica Fedele
Journal: Nat Rev Cancer Date: 2007-12 Impact factor: 60.716

6. Enhancer of zeste homolog 2 overexpression has a role in the development of anaplastic thyroid carcinomas.

Authors: Eleonora Borbone; Giancarlo Troncone; Angelo Ferraro; Zuzana Jasencakova; Lovorka Stojic; Francesco Esposito; Nadine Hornig; Alfredo Fusco; Valerio Orlando
Journal: J Clin Endocrinol Metab Date: 2011-02-02 Impact factor: 5.958

7. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.

Authors: Laura Poliseno; Leonardo Salmena; Jiangwen Zhang; Brett Carver; William J Haveman; Pier Paolo Pandolfi
Journal: Nature Date: 2010-06-24 Impact factor: 49.962

8. NATsDB: Natural Antisense Transcripts DataBase.

Authors: Yong Zhang; Jiongtang Li; Lei Kong; Ge Gao; Qing-Rong Liu; Liping Wei
Journal: Nucleic Acids Res Date: 2006-11-01 Impact factor: 16.971

9. HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness.

Authors: Silvia Pegoraro; Gloria Ros; Silvano Piazza; Roberta Sommaggio; Yari Ciani; Antonio Rosato; Riccardo Sgarra; Giannino Del Sal; Guidalberto Manfioletti
Journal: Oncotarget Date: 2013-08

Review 10. Gene regulation by the act of long non-coding RNA transcription.

Authors: Aleksandra E Kornienko; Philipp M Guenzl; Denise P Barlow; Florian M Pauler
Journal: BMC Biol Date: 2013-05-30 Impact factor: 7.431

19 in total

1. HMGA1-pseudogene expression is induced in human pituitary tumors.

Authors: Francesco Esposito; Marco De Martino; Daniela D'Angelo; Paula Mussnich; Gerald Raverot; Marie-Lise Jaffrain-Rea; Filippo Fraggetta; Jacqueline Trouillas; Alfredo Fusco
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

2. Pseudogene Annexin A2 Pseudogene 1 Contributes to Hepatocellular Carcinoma Progression by Modulating Its Parental Gene ANXA2 via miRNA-376a-3p.

Authors: Huohui Ou; Qingbo Liu; Jie Lin; Wei He; Weijie Zhang; Jing Ma; Weidong Wang
Journal: Dig Dis Sci Date: 2021-01-04 Impact factor: 3.199

Review 3. High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential.

Authors: Lu Wang; Ji Zhang; Min Xia; Chang Liu; Xuyu Zu; Jing Zhong
Journal: Int J Biol Sci Date: 2022-07-04 Impact factor: 10.750

4. The role of HMGA1 protein in gastroenteropancreatic neuroendocrine tumors.

Authors: Marco De Martino; Simona Pellecchia; Francesco Esposito; Nadia Tosti; Cristina Quintavalle; Serenella Eppenberger-Castori; Vincenza Carafa; Alberto Righi; Paolo Chieffi; Alfredo Fusco; Luigi Maria Terracciano; Pierlorenzo Pallante
Journal: Cell Cycle Date: 2022-03-14 Impact factor: 5.173