| Literature DB >> 2548276 |
A Z Kapikian1, J Flores, Y Hoshino, K Midthun, M Gorziglia, K Y Green, R M Chanock, L Potash, S D Sears, M L Clements.
Abstract
Major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. Progress in the development of rotavirus vaccine candidates has also moved swiftly with the "Jennerian" approach, in which a related live, attenuated rotavirus strain from a nonhuman host is used as the immunizing antigen. If this strategy is not effective against all rotavirus serotypes, reassortant rotaviruses hold great promise for the development of a multivalent vaccine. Field trials with the "Jennerian" approach vaccines are under way, and phase 1 trials with the reassortants have been initiated.Entities:
Keywords: Biology; Child Mortality; Clinical Research; Demographic Factors; Developing Countries; Diarrhea; Diarrhea, Infantile--etiology; Diseases; Epidemics; Gastrointestinal Effects; Infant Mortality; Morbidity; Mortality; Physiology; Population; Population Dynamics; Research Methodology; Vaccines; Viral Diseases--etiology
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Year: 1989 PMID： 2548276 DOI： 10.1093/clinids/11.supplement_3.s539
Source DB: PubMed Journal: Rev Infect Dis ISSN： 0162-0886