Literature DB >> 25482624

Tenascin-C Signaling in melanoma.

Hanshuang Shao1, John M Kirkwood, Alan Wells.   

Abstract

Tenascin-C (TNC), a multifunctional matricellular glyco-protein, is highly expressed in the majority of melanoma cell lines and has been implicated in the progression of melanoma. A growing body of evidence has implicated the role of TNC in the process of invasion and metastasis for melanoma. However, the mechanism and individual signaling pathways by which TNC drives melanoma progression have not been illuminated. Herein we provide perspectives from the investigation of TNC in other settings that may hint at the mechanistic role of TNC in this disease.

Entities:  

Keywords:  ECM, extracellular Matrix; EGFL, epidermal growth factor-like; FNIII, fibronectin type III; TNC, Tenascin-C; Tenascin-C; invasion; melanoma; survival

Mesh：

Substances：

Year:  2015        PMID： 25482624      PMCID： PMC4422811          DOI： 10.4161/19336918.2014.972781

Source DB:  PubMed          Journal:  Cell Adh Migr        ISSN： 1933-6918            Impact factor:   3.405


  53 in total

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Journal:  J Cell Sci       Date:  1999-06       Impact factor: 5.285

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  13 in total

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Review 9.  Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma.

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Review 10.  A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer.

Authors:  Dimitrios Korentzelos; Amanda M Clark; Alan Wells
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