Literature DB >> 25482378

One-step synthesis of saturated spirocyclic N-heterocycles with stannyl amine protocol (SnAP) reagents and ketones.

Woon-Yew Siau1, Jeffrey W Bode.   

Abstract

The combination of cyclic ketones and stannyl amine protocol (SnAP) reagents affords saturated, spirocyclic N-heterocycles under operationally simple reaction conditions. The resulting, N-unprotected spirocyclic amines are in great demand as scaffolds for drug discovery and development. The union of SnAP reagents and acyclic trifluoromethylketones yields α-CF3 morpholines and piperazines.

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Year:  2014        PMID： 25482378     DOI： 10.1021/ja511232b

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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