Wei-Sheng Chung1, Feng-Ming Ho2, Nan-Cheng Cheng1, Meng-Chih Lee3, Chih-Jung Yeh4. 1. 1Department of Internal Medicine,Taichung Hospital,Ministry of Health and Welfare,No. 199,Sec. 1,San-Min Road,Taichung City 40343,Taichung,Taiwan. 2. 3Department of Internal Medicine,Taoyuan Hospital,Ministry of Health and Welfare,Taoyuan,Taiwan. 3. 4Department of Family Medicine,Taichung Hospital,Ministry of Health and Welfare,Taichung,Taiwan. 4. 5School of Public Health,Chung-Shan Medical University,Room 1237,No. 110,Sec. 1,Jianguo N. Road,Taichung City 40201,Taiwan.
Abstract
OBJECTIVE: The present study investigates the relationship between BMI and all-cause mortality among middle-aged and older adults with or without pre-existing diseases. DESIGN: A population-based cohort study. SETTING: The Taiwan Longitudinal Study on Aging is a nationwide prospective cohort study comprising a representative random sample of middle-aged and older adults. The study period was 1996-2007. SUBJECTS: We followed 4145 middle-aged and older adults, totalling 42,353 person-years. RESULTS: Overweight and mildly obese participants showed a 16% and 30% decrease in the risk of death, respectively, compared with those of normal weight after adjusting for potential covariates (e.g. demographic characteristics, health behaviour, co-morbidities and physical function). Underweight adults showed a 1.36-fold increased adjusted hazard ratio of death compared with normal-weight adults. Adults with a BMI of 27.0-28.0 kg/m(2) showed a significantly lower adjusted hazard ratio of all-cause mortality rate compared with adults who had normal BMI values when they had coexisting hypertension or diabetes (adjusted hazard ratio = 0.50; 95% CI 0.30, 0.81 for hypertension and adjusted hazard ratio=0.41; 95% CI 0.18, 0.89 for diabetes). CONCLUSIONS: The study demonstrates that underweight people have a higher risk of death, and overweight and mildly obese people have a lower risk of death, compared with people of normal weight among middle-aged and older adults. An optimal BMI may be based on the individual, who exhibits pre-existing diseases or not.
OBJECTIVE: The present study investigates the relationship between BMI and all-cause mortality among middle-aged and older adults with or without pre-existing diseases. DESIGN: A population-based cohort study. SETTING: The Taiwan Longitudinal Study on Aging is a nationwide prospective cohort study comprising a representative random sample of middle-aged and older adults. The study period was 1996-2007. SUBJECTS: We followed 4145 middle-aged and older adults, totalling 42,353 person-years. RESULTS: Overweight and mildly obeseparticipants showed a 16% and 30% decrease in the risk of death, respectively, compared with those of normal weight after adjusting for potential covariates (e.g. demographic characteristics, health behaviour, co-morbidities and physical function). Underweight adults showed a 1.36-fold increased adjusted hazard ratio of death compared with normal-weight adults. Adults with a BMI of 27.0-28.0 kg/m(2) showed a significantly lower adjusted hazard ratio of all-cause mortality rate compared with adults who had normal BMI values when they had coexisting hypertension or diabetes (adjusted hazard ratio = 0.50; 95% CI 0.30, 0.81 for hypertension and adjusted hazard ratio=0.41; 95% CI 0.18, 0.89 for diabetes). CONCLUSIONS: The study demonstrates that underweight people have a higher risk of death, and overweight and mildly obesepeople have a lower risk of death, compared with people of normal weight among middle-aged and older adults. An optimal BMI may be based on the individual, who exhibits pre-existing diseases or not.
Entities:
Keywords:
BMI; Middle-aged and older adults; Mortality; Prospective cohort study
Authors: Ayesha A Javed; Jinhui Ma; Laura N Anderson; Alexandra J Mayhew; Hon Yiu So; Lauren E Griffith; Anne Gilsing; Parminder Raina Journal: Int J Obes (Lond) Date: 2022-01-29 Impact factor: 5.095