Literature DB >> 25481868

The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells.

Jesús M Torres-Flores1, Daniela Silva-Ayala2, Marco A Espinoza3, Susana López4, Carlos F Arias5.   

Abstract

Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was found to function as coreceptor for rotavirus strains RRV, Wa, and UK, but not for rotavirus YM. Reassortant viruses derived from rotaviruses RRV and YM showed that the virus spike protein VP4 determines the use of JAM-A as coreceptor.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  JAM-A; Occludin; Rotavirus; Tight junction proteins; Virus entry; ZO-1

Mesh:

Substances:

Year:  2014        PMID: 25481868     DOI: 10.1016/j.virol.2014.11.016

Source DB:  PubMed          Journal:  Virology        ISSN: 0042-6822            Impact factor:   3.616


  23 in total

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Review 3.  Rotavirus entry: a deep journey into the cell with several exits.

Authors:  Carlos F Arias; Daniela Silva-Ayala; Susana López
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Review 4.  Tight junction proteins occludin and ZO-1 as regulators of epithelial proliferation and survival.

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Journal:  Ann N Y Acad Sci       Date:  2022-05-17       Impact factor: 6.499

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Journal:  J Clin Med       Date:  2022-06-08       Impact factor: 4.964

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Review 8.  Treading a HOSTile path: Mapping the dynamic landscape of host cell-rotavirus interactions to explore novel host-directed curative dimensions.

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Review 10.  Tight Junctions Go Viral!

Authors:  Jesús M Torres-Flores; Carlos F Arias
Journal:  Viruses       Date:  2015-09-23       Impact factor: 5.048

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