Literature DB >> 25481439

Development of topical therapeutics for management of onychomycosis and other nail disorders: a pharmaceutical perspective.

Mustafa M A Elsayed1.   

Abstract

The human nail plate is a formidable barrier to drug permeation. Development of therapeutics for management of nail diseases thus remains a challenge. This article reviews the current knowledge and recent advances in the field of transungual drug delivery and provides guidance on development of topical/ungual therapeutics for management of nail diseases, with special emphasis on management of onychomycosis, the most common nail disease. Selection of drug candidates, drug delivery approaches, and evaluation of formulations are among the topics discussed. A comprehensive mathematical description for transungual permeation is also introduced.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Amorolfine; Antifungal; Ciclopirox; Dermatophytes; Efinaconazole; Keratin binding; Luliconazole; Nail hydration; Nail lacquer; Tavaborole; Terbinafine; Transungual; Transungual penetration enhancer

Mesh：

Substances：

Year:  2014        PMID： 25481439     DOI： 10.1016/j.jconrel.2014.11.017

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  13 in total

1.  In Vitro Human Onychopharmacokinetic and Pharmacodynamic Analyses of ME1111, a New Topical Agent for Onychomycosis.

Authors:  Natsuki Kubota-Ishida; Naomi Takei-Masuda; Kaori Kaneda; Yu Nagira; Tsubasa Chikada; Masahiro Nomoto; Yuji Tabata; Sho Takahata; Kazunori Maebashi; Xiaoying Hui; Howard I Maibach
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

Review 2.  Mechanistic Insights of Formulation Approaches for the Treatment of Nail Infection: Conventional and Novel Drug Delivery Approaches.

Authors:  Agrawal Vikas; Patel Rashmin; Patel Mrunali; Rahul B Chavan; Thanki Kaushik
Journal:  AAPS PharmSciTech       Date:  2020-01-14       Impact factor: 3.246

3.  Once Weekly Application of Urea 40% and Bifonazole 1% Leads to Earlier Nail Removal in Onychomycosis.

Authors:  Avner Shemer; Yossi Eshel; Aditya K Gupta; Renata Farhi; Eckart Haneke; Carlton Ralph Daniel; Kelly Foley; Emma M Quinlan
Journal:  Skin Appendage Disord       Date:  2020-07-13

4.  Luliconazole Nail Lacquer for the Treatment of Onychomycosis: Formulation, Characterization and In Vitro and Ex Vivo Evaluation.

Authors:  Deepa Dehari; Abhishesh Kumar Mehata; Vishnu Priya; Dharmnath Parbat; Deepak Kumar; Anand Kumar Srivastava; Sanjay Singh; Ashish Kumar Agrawal
Journal:  AAPS PharmSciTech       Date:  2022-06-24       Impact factor: 4.026

5.  An investigation of how fungal infection influences drug penetration through onychomycosis patient's nail plates.

Authors:  W J McAuley; S A Jones; M J Traynor; S Guesné; S Murdan; M B Brown
Journal:  Eur J Pharm Biopharm       Date:  2016-03-08       Impact factor: 5.571

6.  In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis.

Authors:  César Augusto Caneschi; Angelina Maria de Almeida; Francislene Juliana Martins; Mireille Le Hyaric; Manoel Marques Evangelista Oliveira; Gilson Costa Macedo; Mauro Vieira de Almeida; Nádia Rezende Barbosa Raposo
Journal:  Braz J Microbiol       Date:  2017-02-09       Impact factor: 2.476

7.  Biopharmaceutical Development of a Bifonazole Multiple Emulsion for Enhanced Epidermal Delivery.

Authors:  Joaquim Suñer-Carbó; Ana Calpena-Campmany; Lyda Halbaut-Bellowa; Beatriz Clares-Naveros; María José Rodriguez-Lagunas; Elena Barbolini; Joanna Zamarbide-Losada; Antonio Boix-Montañés
Journal:  Pharmaceutics       Date:  2019-02-02       Impact factor: 6.321

Review 8.  Onychomycosis: Potential of Nail Lacquers in Transungual Delivery of Antifungals.

Authors:  Nida Akhtar; Hemlata Sharma; Kamla Pathak
Journal:  Scientifica (Cairo)       Date:  2016-03-30

9.  Amorolfine 5% Nail Lacquer Exhibits Potent Antifungal Activity Compared to Three Acid-Based Devices Indicated for the Treatment of Onychomycosis: An In Vitro Nail Penetration Assay.

Authors:  Mahmoud Ghannoum; Karine Sevin; Marlis Sarkany
Journal:  Dermatol Ther (Heidelb)       Date:  2016-02-01

10.  Efficacy Coefficients Determined Using Nail Permeability and Antifungal Activity in Keratin-Containing Media Are Useful for Predicting Clinical Efficacies of Topical Drugs for Onychomycosis.

Authors:  Yoshiki Matsuda; Keita Sugiura; Takashi Hashimoto; Akane Ueda; Yoshihiro Konno; Yoshiyuki Tatsumi
Journal:  PLoS One       Date:  2016-07-21       Impact factor: 3.240
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