Helena Hachul1, Cristina Frange2, Andréia Gomes Bezerra2, Camila Hirotsu2, Gabriel Natan Pires2, Monica Levy Andersen2, Lia Bittencourt2, Sergio Tufik2. 1. Departamento of Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Departamento de Ginecologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP Brazil; Departamento de Ginecologia, Casa de Saúde Santa Marcelina, São Paulo, SP, Brazil. Electronic address: helena.hachul@hotmail.com. 2. Departamento of Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Abstract
OBJECTIVE: Our objective was to investigate the influence of menopausal status on sleep patterns in a representative sample of women from São Paulo, Brazil. STUDY DESIGN: A population-based survey with a probabilistic three-stage cluster sample of the city of São Paulo was used to represent the local population according to gender, age (20-80 years) and socioeconomic status. MAIN OUTCOME MEASURES: The female participants answered a sleep questionnaire, underwent polysomnographic recording and allowed their hormone levels to be measured. They also completed a gynecological questionnaire for classification of the reproductive aging stages: premenopausal or reproductive, perimenopausal or menopausal transition, and postmenopausal, defined as being after 12 months of amenorrhea. Women were allocated into early (the first 5 years after menopause) and late (after the first 5 years) stages. RESULTS: A total of 535 women were included in this study: 339 were premenopausal, 53 were early postmenopausal, 118 were late postmenopausal and 25 were using hormone therapy or isoflavone compounds. Our main findings were that women in postmenopause spent more time in N3 sleep, had a higher apnea-hypopnea index (AHI) and lower SaO2 compared with premenopausal women after an analysis adjusted for confounding factors. We found no significant differences between early and late postmenopausal women in the adjusted analysis. CONCLUSION: Our results indicate menopause itself exerts a modest, but important influence on objective sleep patterns, independent of age, in particular on AHI and SaO2.
OBJECTIVE: Our objective was to investigate the influence of menopausal status on sleep patterns in a representative sample of women from São Paulo, Brazil. STUDY DESIGN: A population-based survey with a probabilistic three-stage cluster sample of the city of São Paulo was used to represent the local population according to gender, age (20-80 years) and socioeconomic status. MAIN OUTCOME MEASURES: The female participants answered a sleep questionnaire, underwent polysomnographic recording and allowed their hormone levels to be measured. They also completed a gynecological questionnaire for classification of the reproductive aging stages: premenopausal or reproductive, perimenopausal or menopausal transition, and postmenopausal, defined as being after 12 months of amenorrhea. Women were allocated into early (the first 5 years after menopause) and late (after the first 5 years) stages. RESULTS: A total of 535 women were included in this study: 339 were premenopausal, 53 were early postmenopausal, 118 were late postmenopausal and 25 were using hormone therapy or isoflavone compounds. Our main findings were that women in postmenopause spent more time in N3 sleep, had a higher apnea-hypopnea index (AHI) and lower SaO2 compared with premenopausal women after an analysis adjusted for confounding factors. We found no significant differences between early and late postmenopausal women in the adjusted analysis. CONCLUSION: Our results indicate menopause itself exerts a modest, but important influence on objective sleep patterns, independent of age, in particular on AHI and SaO2.
Authors: Erla S Sigurðardóttir; Thorarinn Gislason; Bryndis Benediktsdottir; Steinar Hustad; Payam Dadvand; Pascal Demoly; Karl A Franklin; Joachim Heinrich; Mathias Holm; Diana A van der Plaat; Rain Jõgi; Benedicte Leynaert; Eva Lindberg; Jesus Martinez-Moratalla; Leire Sainz De Aja; Giancarlo Pesce; Isabelle Pin; Chantal Raherison; Antonio Pereira-Vega; Francisco Gómez Real; Kai Triebner Journal: PLoS One Date: 2022-06-22 Impact factor: 3.752
Authors: Han Chen; Brian E Cade; Kevin J Gleason; Andrew C Bjonnes; Adrienne M Stilp; Tamar Sofer; Matthew P Conomos; Sonia Ancoli-Israel; Raanan Arens; Ali Azarbarzin; Graeme I Bell; Jennifer E Below; Sung Chun; Daniel S Evans; Ralf Ewert; Alexis C Frazier-Wood; Sina A Gharib; José Haba-Rubio; Erika W Hagen; Raphael Heinzer; David R Hillman; W Craig Johnson; Zoltan Kutalik; Jacqueline M Lane; Emma K Larkin; Seung Ku Lee; Jingjing Liang; Jose S Loredo; Sutapa Mukherjee; Lyle J Palmer; George J Papanicolaou; Thomas Penzel; Paul E Peppard; Wendy S Post; Alberto R Ramos; Ken Rice; Jerome I Rotter; Scott A Sands; Neomi A Shah; Chol Shin; Katie L Stone; Beate Stubbe; Jae Hoon Sul; Mehdi Tafti; Kent D Taylor; Alexander Teumer; Timothy A Thornton; Gregory J Tranah; Chaolong Wang; Heming Wang; Simon C Warby; D Andrew Wellman; Phyllis C Zee; Craig L Hanis; Cathy C Laurie; Daniel J Gottlieb; Sanjay R Patel; Xiaofeng Zhu; Shamil R Sunyaev; Richa Saxena; Xihong Lin; Susan Redline Journal: Am J Respir Cell Mol Biol Date: 2018-03 Impact factor: 6.914