Rezwan Ghassemi1, Robert Brown1, Brenda Banwell2, Sridar Narayanan1, Douglas L Arnold3. 1. Montreal Neurological Institute, McGill University, Montreal, QC, Canada. 2. The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; The Children's Hospital of Philadelphia, Philadelphia, USA. 3. Montreal Neurological Institute, McGill University, Montreal, QC, Canada douglas.arnold@mcgill.ca.
Abstract
BACKGROUND: Children and adolescents with relapsing-remitting multiple sclerosis (RRMS) have a similar T2 lesion burden as adults matched for disease duration. However, it is unknown whether the degree of tissue destruction within lesions is also similar. Persistent reduced T1-weighted signal intensity within lesions indicates loss of tissue integrity. OBJECTIVE: We aimed to compare change over a 2-year period in T1 intensity within new T2 lesions, from pre-lesion levels to chronic post-lesion levels, between pediatric and adult-onset MS. METHODS: A two-point intensity-normalization method was used to generate normalized T1-weighted (NT1) images from T1-weighted data in 29 pediatric MS patients (age(mean±SD, years), disease duration (years)=15.7±2.4, 3.9±2.6) and 24 adult MS patients (36.7±8.9, 6.9±4.8). Subjects were imaged at three consecutive timepoints, 1 year apart. For each subject, a 'new-T2' lesion mask was created and the NT1 intensities 'pre-lesion', 'peri-lesion' and 'post-lesion' were determined. A longitudinal model was used to capture NT1 changes. RESULTS: The NT1 in both groups failed to recover to pre-lesion values by 1 year post-lesion (p=0.0002), with children showing significantly better recovery than adults (p=0.0089). CONCLUSIONS: Both groups showed a significant chronic reduction of T1 intensity within new T2 lesions. However, children showed a significantly greater recovery of T1 intensity, suggesting that MS lesions in the pediatric MS population are less destructive, or that pediatric patients have greater reparative capacity.
BACKGROUND:Children and adolescents with relapsing-remitting multiple sclerosis (RRMS) have a similar T2 lesion burden as adults matched for disease duration. However, it is unknown whether the degree of tissue destruction within lesions is also similar. Persistent reduced T1-weighted signal intensity within lesions indicates loss of tissue integrity. OBJECTIVE: We aimed to compare change over a 2-year period in T1 intensity within new T2 lesions, from pre-lesion levels to chronic post-lesion levels, between pediatric and adult-onset MS. METHODS: A two-point intensity-normalization method was used to generate normalized T1-weighted (NT1) images from T1-weighted data in 29 pediatric MS patients (age(mean±SD, years), disease duration (years)=15.7±2.4, 3.9±2.6) and 24 adult MS patients (36.7±8.9, 6.9±4.8). Subjects were imaged at three consecutive timepoints, 1 year apart. For each subject, a 'new-T2' lesion mask was created and the NT1 intensities 'pre-lesion', 'peri-lesion' and 'post-lesion' were determined. A longitudinal model was used to capture NT1 changes. RESULTS: The NT1 in both groups failed to recover to pre-lesion values by 1 year post-lesion (p=0.0002), with children showing significantly better recovery than adults (p=0.0089). CONCLUSIONS: Both groups showed a significant chronic reduction of T1 intensity within new T2 lesions. However, children showed a significantly greater recovery of T1 intensity, suggesting that MS lesions in the pediatric MS population are less destructive, or that pediatric patients have greater reparative capacity.
Authors: Jean-Philippe Fortin; Elizabeth M Sweeney; John Muschelli; Ciprian M Crainiceanu; Russell T Shinohara Journal: Neuroimage Date: 2016-02-23 Impact factor: 6.556
Authors: Menghan Hu; Ciprian Crainiceanu; Matthew K Schindler; Blake Dewey; Daniel S Reich; Russell T Shinohara; Ani Eloyan Journal: Biostatistics Date: 2022-01-13 Impact factor: 5.279
Authors: Elizabeth M Sweeney; Russell T Shinohara; Blake E Dewey; Matthew K Schindler; John Muschelli; Daniel S Reich; Ciprian M Crainiceanu; Ani Eloyan Journal: Neuroimage Clin Date: 2015-11-11 Impact factor: 4.881
Authors: Julio Zaki Abucham-Neto; André Augusto Miranda Torricelli; Aline Cristina Fioravanti Lui; Sarah Napoli Guimarães; Heloisa Nascimento; Caio Vinícius Regatieri Journal: Int J Retina Vitreous Date: 2018-04-16