Literature DB >> 2547965

Rhesus macaques inoculated with molecularly cloned simian immunodeficiency virus.

M L Marthas1, B Banapour, S Sutjipto, M E Siegel, P A Marx, M B Gardner, N C Pedersen, P A Luciw.   

Abstract

We have isolated a biologically active molecular clone of simian immunodeficiency virus (SIV), SIVmac 1A11, originally obtained from a rhesus macaque at the New England Regional Primate Research Center. Virus derived from cells transfected with this clone is cytopathic for rhesus peripheral blood mononuclear cells, replicates in cultures of rhesus macrophages, and infects rhesus macaques when inoculated intravenously. Six macaques inoculated with SIVmac 1A11 all became infected and produced antibodies to viral envelope glycoproteins that neutralized virus. Antibodies to viral core proteins were detected in only one animal. No clinical signs of disease were observed throughout 7 months postinoculation.

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Year:  1989        PMID： 2547965

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  36 in total

1.  Highly uneven distribution of tenofovir-selected simian immunodeficiency virus in different anatomical sites of rhesus macaques.

Authors:  Magdalena Magierowska; Flavien Bernardin; Seema Garg; Silvija Staprans; Michael D Miller; Koen K A Van Rompay; Eric L Delwart
Journal:  J Virol       Date:  2004-03       Impact factor: 5.103

2.  Inactivated whole-virus vaccine derived from a proviral DNA clone of simian immunodeficiency virus induces high levels of neutralizing antibodies and confers protection against heterologous challenge.

Authors:  P R Johnson; D C Montefiori; S Goldstein; T E Hamm; J Zhou; S Kitov; N L Haigwood; L Misher; W T London; J L Gerin
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

3.  Differential functional phenotypes of two primary HIV-1 strains resulting from homologous point mutations in the LLP domains of the envelope gp41 intracytoplasmic domain.

Authors:  Jason T Newman; Timothy J Sturgeon; Phalguni Gupta; Ronald C Montelaro
Journal:  Virology       Date:  2007-06-19       Impact factor: 3.616

4.  Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239.

Authors:  C J Miller; M B McChesney; X Lü; P J Dailey; C Chutkowski; D Lu; P Brosio; B Roberts; Y Lu
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

5.  Effects of stabilization of the gp41 cytoplasmic domain on fusion activity and infectivity of SIVmac239.

Authors:  Andrei N Vzorov; Richard W Compans
Journal:  AIDS Res Hum Retroviruses       Date:  2011-05-04       Impact factor: 2.205

6.  Vaginal transmission of chimeric simian/human immunodeficiency viruses in rhesus macaques.

Authors:  Y Lu; P Brosio; M Lafaile; J Li; R G Collman; J Sodroski; C J Miller
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

7.  Immunization of newborn rhesus macaques with simian immunodeficiency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251.

Authors:  Koen K A Van Rompay; Jennifer L Greenier; Kelly Stefano Cole; Patricia Earl; Bernard Moss; Jonathan D Steckbeck; Bapi Pahar; Tracy Rourke; Ronald C Montelaro; Don R Canfield; Ross P Tarara; Christopher Miller; Michael B McChesney; Marta L Marthas
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

8.  Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus.

Authors:  J E Clements; R C Montelaro; M C Zink; A M Amedee; S Miller; A M Trichel; B Jagerski; D Hauer; L N Martin; R P Bohm
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

9.  Identification of viral determinants of macrophage tropism for simian immunodeficiency virus SIVmac.

Authors:  B Banapour; M L Marthas; R A Ramos; B L Lohman; R E Unger; M B Gardner; N C Pedersen; P A Luciw
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

10.  Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia.

Authors:  C J Miller; M Marthas; J Torten; N J Alexander; J P Moore; G F Doncel; A G Hendrickx
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103
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