| Literature DB >> 2547959 |
W R Morton1, L Kuller, R E Benveniste, E A Clark, C C Tsai, M J Gale, M E Thouless, J Overbaugh, M G Katze.
Abstract
A primate lymphotropic lentivirus was isolated on Hut 78 cells after cocultivation of a lymph node from a macaque that died with malignant lymphoma. In earlier studies SIV/Mne was inoculated into 17 macaques and two baboons. All of the macaques became viremic and seropositive. Fifteen of the macaques succumbed to a classic AIDS-like disease, whereas the baboons did not become viremic. The SIV/Mne virus has now been molecularly cloned and inoculated into Macaca nemestrina and baboons. A new transmission study has been initiated to test the effects of route and dosage on disease.Entities:
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Year: 1989 PMID： 2547959
Source DB: PubMed Journal: J Med Primatol ISSN： 0047-2565 Impact factor: 0.667