Literature DB >> 2547892

[3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients.

J Kornhuber1, F Mack-Burkhardt, P Riederer, G F Hebenstreit, G P Reynolds, H B Andrews, H Beckmann.   

Abstract

[3H]MK-801 binding was used as a marker for the NMDA receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.

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Year:  1989        PMID： 2547892     DOI： 10.1007/BF01248936

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  21 in total

Review 1.  Phencyclidine: an overview.

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3.  Neurotransmitters, receptors and neuropeptides in post-mortem brains of chronic schizophrenic patients.

Authors:  M Toru; S Watanabe; H Shibuya; T Nishikawa; K Noda; H Mitsushio; H Ichikawa; A Kurumaji; M Takashima; N Mataga
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4.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

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5.  Chronic haloperidol treatment up-regulates rat brain PCP receptors.

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6.  No D2 receptor increase in PET study of schizophrenia.

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Authors:  R M Allen; S J Young
Journal:  Am J Psychiatry       Date:  1978-09       Impact factor: 18.112

8.  Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia.

Authors:  T Nishikawa; M Takashima; M Toru
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9.  Calcium dependent aspects of synaptic plasticity, excitatory amino acid neurotransmission, brain aging and schizophrenia: a unifying hypothesis.

Authors:  P Etienne; M Baudry
Journal:  Neurobiol Aging       Date:  1987 Jul-Aug       Impact factor: 4.673

10.  Mode of binding of [3H]dibenzocycloalkenimine (MK-801) to the N-methyl-D-aspartate (NMDA) receptor and its therapeutic implication.

Authors:  Y Kloog; V Nadler; M Sokolovsky
Journal:  FEBS Lett       Date:  1988-03-28       Impact factor: 4.124
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  32 in total

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7.  NMDA receptor and schizophrenia: a brief history.

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Review 9.  Kynurenines and intestinal neurotransmission: the role of N-methyl-D-aspartate receptors.

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10.  Amantadine and the glutamate hypothesis of schizophrenia. Experiences in the treatment of neuroleptic malignant syndrome.

Authors:  J Kornhuber; M Weller
Journal:  J Neural Transm Gen Sect       Date:  1993
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