A R Somashekar1, Ashwini B Prithvi2, M N Vanitha Gowda3. 1. Professor, Department of Paediatrics, M S Ramaiah Medical College and Hospitals , Bangalore, India . 2. Intern, Department of Paediatrics, M S Ramaiah Medical College and Hospitals , Bangalore, India . 3. Associate Professor, Department of Biochemistry, M S Ramaiah Medical College and Hospitals , Bangalore, India .
Abstract
INTRODUCTION: Bronchial Asthma is a common chronic inflammatory disorder of the airways in childhood. Vitamin-D, required for bone mineralization, is also a potent immune system regulator having a potential role in various allergic diseases. This study was undertaken to determine the difference in serum levels of Vitamin-D in asthmatic children and to determine the association between vitamin-D and asthma in children. MATERIALS AND METHODS: This cross-sectional study included 88 (44 asthmatic children and 44 healthy controls) children aged between 5 and 13 y. Serum 25-hydroxy vitamin-D levels were determined and compared between the two groups. The association between vitamin-D levels and lung function was studied in the asthmatic children. RESULTS: Serum vitamin-D level was significantly lower in asthmatic children than in control group and in the asthmatic group, vitamin-D levels had a significant positive correlation with FEV1% and FEV1/FVC%. CONCLUSION: Vitamin-D deficiency is highly prevalent in asthmatic children and is associated with airway limitation.
INTRODUCTION:Bronchial Asthma is a common chronic inflammatory disorder of the airways in childhood. Vitamin-D, required for bone mineralization, is also a potent immune system regulator having a potential role in various allergic diseases. This study was undertaken to determine the difference in serum levels of Vitamin-D in asthmatic children and to determine the association between vitamin-D and asthma in children. MATERIALS AND METHODS: This cross-sectional study included 88 (44 asthmatic children and 44 healthy controls) children aged between 5 and 13 y. Serum 25-hydroxy vitamin-D levels were determined and compared between the two groups. The association between vitamin-D levels and lung function was studied in the asthmatic children. RESULTS: Serum vitamin-D level was significantly lower in asthmatic children than in control group and in the asthmatic group, vitamin-D levels had a significant positive correlation with FEV1% and FEV1/FVC%. CONCLUSION:Vitamin-D deficiency is highly prevalent in asthmatic children and is associated with airway limitation.
Authors: Nasser M Al-Daghri; Omar S Al-Attas; Sobhy M Yakout; Abdullah M Alnaami; Kaiser Wani; Majed S Alokail Journal: Medicine (Baltimore) Date: 2018-09 Impact factor: 1.817