Literature DB >> 25478418

A comparative study on the efficacy of glucose and sucrose on the vaccination pain: a randomized controlled clinical trial.

Zainab Suhrabi1, Hamid Taghinejad2, Kobra Valian3, Kourosh Sayehmiri4, Safoura Taheri1.   

Abstract

OBJECTIVES: This study was performed to compare the effectiveness of two analgesics for the management of vaccination pain.
MATERIALS AND METHODS: A total of 90 neonates to be vaccinated against Hepatitis B were assigned to Glucose, Sucrose and control groups at Shahid Mostafa Khomini hospital. 2cc oral Glucose 25% and 2cc oral Sucrose 25% with Syringe were given for 30 sec then 2 min later Hepatitis-B vaccine injected by vaccinator and pain intensity measured by Neonatal Infant Pain Scale (NIPS) during 1-2 min. The third group (control) no intervention was performed. The collected data were analysed by SPSS18 Software and ANOVA and LSD tests were used.
RESULTS: Research results showed that there were no significant differences between groups in term of Apgar score, delivery type, sex, head circumstance, weight and height. By comparison of pain severity in two groups, mean and Standard deviation of pain, group that received Glucose solution had more intensity than Sucrose group (3 ± 1.66 vs. 2.90 ± 1.44), but this difference was not significant statistically (p=0.78). Comparison of pain intensity in control and intervention groups showed that the pain intensity in control group is higher than intervention groups (p<0.001).
CONCLUSION: Patients who received Glucose or Sucrose had lower pain intensity in comparison with the other. The pain intensity in patients who received sucrose was less than the glucose group, but this difference was not significant statistically.

Entities:  

Keywords:  Glucose; Pain; Sucrose; Vaccination

Year:  2014        PMID: 25478418      PMCID: PMC4253236          DOI: 10.7860/JCDR/2014/10057.5053

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  12 in total

1.  Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates.

Authors:  R Carbajal; X Chauvet; S Couderc; M Olivier-Martin
Journal:  BMJ       Date:  1999-11-27

2.  Comparison between massage and music therapies to relieve the severity of labor pain.

Authors:  Hamid Taghinejad; Ali Delpisheh; Zeinab Suhrabi
Journal:  Womens Health (Lond)       Date:  2010-05

3.  The role of endogenous opioids in mediating pain reduction by orally administered glucose among newborns.

Authors:  Maria Gradin; Jens Schollin
Journal:  Pediatrics       Date:  2005-04       Impact factor: 7.124

4.  The use of oral sucrose for procedural pain relief in infants up to six months of age: a randomized controlled trial.

Authors:  Sally Wilson; Alexandra P Bremner; Judy Mathews; Diane Pearson
Journal:  Pain Manag Nurs       Date:  2012-01-09       Impact factor: 1.929

Review 5.  Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review.

Authors:  Denise Harrison; Bonnie Stevens; Mariana Bueno; Janet Yamada; Thomasin Adams-Webber; Joseph Beyene; Arne Ohlsson
Journal:  Arch Dis Child       Date:  2010-05-12       Impact factor: 3.791

Review 6.  Mechanisms of sucrose and non-nutritive sucking in procedural pain management in infants.

Authors:  S Gibbins; B Stevens
Journal:  Pain Res Manag       Date:  2001       Impact factor: 3.037

7.  Feeding and oral glucose--additive effects on pain reduction in newborns.

Authors:  Maria Gradin; Orvar Finnström; Jens Schollin
Journal:  Early Hum Dev       Date:  2004-04       Impact factor: 2.079

8.  Infant physiological responses to noxious stimuli of circumcision with anesthesia and analgesia.

Authors:  T L Olson; V W Downey
Journal:  Pediatr Nurs       Date:  1998 Jul-Aug

9.  Oral glucose as an analgesic to reduce infant distress following immunization at the age of 3, 5 and 12 months.

Authors:  Margit Thyr; Anneli Sundholm; Lawrence Teeland; Vivi-Anne Rahm
Journal:  Acta Paediatr       Date:  2007-02       Impact factor: 2.299

10.  A comparative study on the efficacy of Ibuprofen and celecoxib on the intensity of perineal pain following episiotomy: a randomized clinical trial.

Authors:  Zainab Suhrabi; Hamid Taghinejad
Journal:  Iran Red Crescent Med J       Date:  2013-12-05       Impact factor: 0.611

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  4 in total

Review 1.  Sucrose for analgesia in newborn infants undergoing painful procedures.

Authors:  Bonnie Stevens; Janet Yamada; Arne Ohlsson; Sarah Haliburton; Allyson Shorkey
Journal:  Cochrane Database Syst Rev       Date:  2016-07-16

2.  Comparison of iatrogenic pain between rotavirus vaccination before and after vaccine injection in 2-month-old infants.

Authors:  Hui-Chu Yin; Whei-Mei Shih; Hsiu-Lan Lee; Huei-Jing Yang; Yu-Li Chen; Shao-Wen Cheng; Chun-Yuh Yang; Ya-Wen Chiu; Yi-Hao Weng
Journal:  Hum Vaccin Immunother       Date:  2017-01-06       Impact factor: 3.452

3.  First Brazilian recommendation on physiotherapy with sensory motor stimulation in newborns and infants in the intensive care unit.

Authors:  Cíntia Johnston; Mônica Sanchez Stopiglia; Simone Nascimento Santos Ribeiro; Cristiane Sousa Nascimento Baez; Silvana Alves Pereira
Journal:  Rev Bras Ter Intensiva       Date:  2021 Jan-Mar

4.  Development of locally relevant clinical guidelines for procedure-related neonatal analgesic practice in Kenya: a systematic review and meta-analysis.

Authors:  Cian Wade; John Scott Frazer; Evelyn Qian; Lien M Davidson; Suzanne Dash; Anna Te Water Naudé; Rema Ramakrishan; Jalemba Aluvaala; Kokila Lakhoo; Mike English
Journal:  Lancet Child Adolesc Health       Date:  2020-07-28
  4 in total

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