Sayantan Ray1, Dibbendhu Khanra2, Nikhil Sonthalia2, Supratip Kundu3, Kaushik Biswas4, Arunansu Talukdar5, Manjari Saha6, Himel Bera7. 1. Residential Medical Officer, Department of Medicine, Calcutta National Medical College and Hospital , Kolkata, India . 2. Resident, Department of Medicine, Medical College and Hospital , Kolkata, India . 3. Resident, Department of Cardiology, Medical College and Hospital , Kolkata, India . 4. Senior Resident, Department of Endocrinology, Institute of Post Graduate Medical Education & Research (IPGMER) and SSKM Hospital , Kolkata, India . 5. Professor, Department of Medicine, Medical College and Hospital , Kolkata, India . 6. Assistant Professor, Department of Medicine, Medical College and Hospital , Kolkata, India . 7. Assistant Professor, Department of Pathology, Bankura Sammilani Medical College & Hospital , Bankura, India .
Abstract
BACKGROUND: Alcoholism is a health problem not only in developed countries but also in developing countries. Cirrhosis due to alcohol is a common cause of death among individuals abusing alcohol. A better knowledge of the spectrum of alcoholic liver diseases, its clinical, biochemical and histopathological features could result in early detection and prevention of alcoholic liver diseases before it's catastrophic and life threatening effects. MATERIALS AND METHODS: A total of 200 patients with alcoholic liver diseases were studied with respect to alcohol consumption, clinical features, biochemical and histopathological changes. The clinical features, biochemical parameters, and histopathology of liver including Ishak's modified histological activity index (HAI) were correlated with the amount and duration of alcohol consumed. RESULT: Majority of the patients were in the age group of 40-49 years and all the cases were males. Majority consumed alcohol of about 75-90 grams per day for a duration of 10-12 years. Anorexia and jaundice were the most common symptom and clinical finding respectively. Hyperbilirubinemia and hypoalbuminemia were the most common abnormalities observed in liver function tests. Advanced HAI stages with features of cirrhosis were most frequent histo-pathological finding noted in this study. Clinico-biochemical profile was significantly correlated with degree of alcohol ingestion as well as with liver histopathology. CONCLUSION: The wide prevalence of alcoholic liver disease including cirrhosis among Indian males was noted with significantly lower quantity and duration of alcohol ingestion. The severity of liver damage is directly proportional to the quantity and duration of alcohol consumed. Clinical features and biochemical changes may forecast the liver histopathology among the patients of alcoholic liver disease.
BACKGROUND: Alcoholism is a health problem not only in developed countries but also in developing countries. Cirrhosis due to alcohol is a common cause of death among individuals abusing alcohol. A better knowledge of the spectrum of alcoholic liver diseases, its clinical, biochemical and histopathological features could result in early detection and prevention of alcoholic liver diseases before it's catastrophic and life threatening effects. MATERIALS AND METHODS: A total of 200 patients with alcoholic liver diseases were studied with respect to alcohol consumption, clinical features, biochemical and histopathological changes. The clinical features, biochemical parameters, and histopathology of liver including Ishak's modified histological activity index (HAI) were correlated with the amount and duration of alcohol consumed. RESULT: Majority of the patients were in the age group of 40-49 years and all the cases were males. Majority consumed alcohol of about 75-90 grams per day for a duration of 10-12 years. Anorexia and jaundice were the most common symptom and clinical finding respectively. Hyperbilirubinemia and hypoalbuminemia were the most common abnormalities observed in liver function tests. Advanced HAI stages with features of cirrhosis were most frequent histo-pathological finding noted in this study. Clinico-biochemical profile was significantly correlated with degree of alcohol ingestion as well as with liver histopathology. CONCLUSION: The wide prevalence of alcoholic liver disease including cirrhosis among Indian males was noted with significantly lower quantity and duration of alcohol ingestion. The severity of liver damage is directly proportional to the quantity and duration of alcohol consumed. Clinical features and biochemical changes may forecast the liver histopathology among the patients of alcoholic liver disease.
Entities:
Keywords:
Alcoholic liver diseases; Amount; Duration; Histopathology; Liver function tests
Authors: K Ishak; A Baptista; L Bianchi; F Callea; J De Groote; F Gudat; H Denk; V Desmet; G Korb; R N MacSween Journal: J Hepatol Date: 1995-06 Impact factor: 25.083
Authors: Isabel Legaz; Jose Miguel Bolarín; Elena Navarro; Jose Antonio Campillo; Rosa Moya; María Dolores Pérez-Cárceles; Aurelio Luna; Eduardo Osuna; Manuel Miras; Manuel Muro; Alfredo Minguela; Rocio Alvarez López Journal: Arch Med Sci Date: 2019-04-09 Impact factor: 3.318