Literature DB >> 25477522

Spore photoproduct lyase: the known, the controversial, and the unknown.

Linlin Yang1, Lei Li2.   

Abstract

Spore photoproduct lyase (SPL) repairs 5-thyminyl-5,6-dihydrothymine, a thymine dimer that is also called the spore photoproduct (SP), in germinating endospores. SPL is a radical S-adenosylmethionine (SAM) enzyme, utilizing the 5'-deoxyadenosyl radical generated by SAM reductive cleavage reaction to revert SP to two thymine residues. Here we review the current progress in SPL mechanistic studies. Protein radicals are known to be involved in SPL catalysis; however, how these radicals are quenched to close the catalytic cycle is under debate.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  DNA Repair; DNA-Protein Interaction; Enzyme Catalysis; Enzyme Mechanism; Radiation Biology; Radical; Redox

Mesh：

Substances：

Year:  2014        PMID： 25477522      PMCID： PMC4326811          DOI： 10.1074/jbc.R114.573675

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  88 in total

1.  Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species.

Authors:  Ki Seog Lee; Daniela Bumbaca; Jeffrey Kosman; Peter Setlow; Mark J Jedrzejas
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-19       Impact factor: 11.205

2.  Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases.

Authors:  Farhad Forouhar; Simon Arragain; Mohamed Atta; Serge Gambarelli; Jean-Marie Mouesca; Munif Hussain; Rong Xiao; Sylvie Kieffer-Jaquinod; Jayaraman Seetharaman; Thomas B Acton; Gaetano T Montelione; Etienne Mulliez; John F Hunt; Marc Fontecave
Journal:  Nat Chem Biol       Date:  2013-03-31       Impact factor: 15.040

3.  Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.

Authors:  Bradley M Hover; Anna Loksztejn; Anthony A Ribeiro; Kenichi Yokoyama
Journal:  J Am Chem Soc       Date:  2013-04-29       Impact factor: 15.419

4.  Evidence for the monomerization of spore photoproduct to two thymines by the light-independent "spore repair" process in Bacillus subtilis.

Authors:  T C Van Wang; C S Rupert
Journal:  Photochem Photobiol       Date:  1977-01       Impact factor: 3.421

5.  Genetically controlled removal of "spore photoproduct" from deoxyribonucleic acid of ultraviolet-irradiated Bacillus subtilis spores.

Authors:  N Munakata; C S Rupert
Journal:  J Bacteriol       Date:  1972-07       Impact factor: 3.490

6.  Dark repair of DNA containing "spore photoproduct" in Bacillus subtilis.

Authors:  N Munakata; C S Rupert
Journal:  Mol Gen Genet       Date:  1974-05-31

7.  Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate.

Authors:  Laure Decamps; Benjamin Philmus; Alhosna Benjdia; Robert White; Tadhg P Begley; Olivier Berteau
Journal:  J Am Chem Soc       Date:  2012-10-24       Impact factor: 15.419

8.  GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.

Authors:  Hak Joong Kim; Reid M McCarty; Yasushi Ogasawara; Yung-nan Liu; Steven O Mansoorabadi; Jake LeVieux; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2013-05-21       Impact factor: 15.419

9.  A radical transfer pathway in spore photoproduct lyase.

Authors:  Linlin Yang; Renae S Nelson; Alhosna Benjdia; Gengjie Lin; Joshua Telser; Stefan Stoll; Ilme Schlichting; Lei Li
Journal:  Biochemistry       Date:  2013-04-22       Impact factor: 3.162

10.  Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.

Authors:  Kevin P McCusker; Katalin F Medzihradszky; Anthony L Shiver; Robert J Nichols; Feng Yan; David A Maltby; Carol A Gross; Danica Galonić Fujimori
Journal:  J Am Chem Soc       Date:  2012-10-22       Impact factor: 15.419
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  10 in total

1.  Role of DNA Repair and Protective Components in Bacillus subtilis Spore Resistance to Inactivation by 400-nm-Wavelength Blue Light.

Authors:  Bahar Djouiai; Joanne E Thwaite; Thomas R Laws; Fabian M Commichau; Barbara Setlow; Peter Setlow; Ralf Moeller
Journal:  Appl Environ Microbiol       Date:  2018-09-17       Impact factor: 4.792

2.  Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme-The spore photoproduct lyase.

Authors:  Linlin Yang; Yajun Jian; Peter Setlow; Lei Li
Journal:  DNA Repair (Amst)       Date:  2017-03-06

3.  Kinetic Isotope Effects and Hydrogen/Deuterium Exchange Reveal Large Conformational Changes During the Catalysis of the Clostridium acetobutylicum Spore Photoproduct Lyase.

Authors:  Linlin Yang; Jagat Adhikari; Michael L Gross; Lei Li
Journal:  Photochem Photobiol       Date:  2017-01-30       Impact factor: 3.421

Review 4.  Introduction to the thematic minireview series on radical S-adenosylmethionine (SAM) enzymes.

Authors:  Ruma Banerjee
Journal:  J Biol Chem       Date:  2014-12-04       Impact factor: 5.157

Review 5.  Photochemistry and Photobiology of the Spore Photoproduct: A 50-Year Journey.

Authors:  Peter Setlow; Lei Li
Journal:  Photochem Photobiol       Date:  2015-09-20       Impact factor: 3.421

Review 6.  The origin and evolution of ribonucleotide reduction.

Authors:  Daniel Lundin; Gustav Berggren; Derek T Logan; Britt-Marie Sjöberg
Journal:  Life (Basel)       Date:  2015-02-27

7.  Insights into the Activity Change of Spore Photoproduct Lyase Induced by Mutations at a Peripheral Glycine Residue.

Authors:  Linlin Yang; Lei Li
Journal:  Front Chem       Date:  2017-03-28       Impact factor: 5.221

8.  The small acid-soluble proteins of Clostridioides difficile are important for UV resistance and serve as a check point for sporulation.

Authors:  Hailee N Nerber; Joseph A Sorg
Journal:  PLoS Pathog       Date:  2021-09-08       Impact factor: 6.823

Review 9.  Small Prokaryotic DNA-Binding Proteins Protect Genome Integrity throughout the Life Cycle.

Authors:  Katja Molan; Darja Žgur Bertok
Journal:  Int J Mol Sci       Date:  2022-04-04       Impact factor: 5.923

Review 10.  Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL.

Authors:  Wei Ding; Xinjian Ji; Yongzhen Li; Qi Zhang
Journal:  Front Chem       Date:  2016-06-22       Impact factor: 5.221
  10 in total

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