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Literature DB >> 25476855

Augmented TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells.

Chenggang Li¹, Zhiming Zhao, Zhipeng Zhou, Rong Liu.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant tumor in humans. Thus, understanding the tumorigenesis of PDAC appears to help develop efficient therapy. Here, we show that activated TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells in vitro and in vivo, suggesting that activation of TGFβ receptor signaling may prevent development of PDAC.

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Year: 2014 PMID： 25476855 DOI： 10.1007/s13277-014-2908-7

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

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References

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Augmented TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells.

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