Literature DB >> 25476732

Hepatocyte growth factor: A regulator of inflammation and autoimmunity.

Nicolas Molnarfi1, Mahdia Benkhoucha1, Hiroshi Funakoshi2, Toshikazu Nakamura3, Patrice H Lalive4.   

Abstract

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Autoimmune regulator; Autoimmunity; HGF; Inflammation; Therapy; c-Met

Mesh：

Substances：

Year:  2014        PMID： 25476732     DOI： 10.1016/j.autrev.2014.11.013

Source DB:  PubMed          Journal:  Autoimmun Rev        ISSN： 1568-9972            Impact factor:   9.754


  44 in total

1.  Identification of a novel population of highly cytotoxic c-Met-expressing CD8+ T lymphocytes.

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Journal:  J Infect Dis       Date:  2017-07-15       Impact factor: 5.226

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Review 5.  Recent advances in the therapeutic efficacy of hepatocyte growth factor gene-modified mesenchymal stem cells in multiple disease settings.

Authors:  Hong-Fang Meng; Jide Jin; Hua Wang; Li-Sheng Wang; Chu-Tse Wu
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8.  CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation.

Authors:  Mahdia Benkhoucha; Ngoc Lan Tran; Gautier Breville; Isis Senoner; Paul F Bradfield; Thalia Papayannopoulou; Doron Merkler; Thomas Korn; Patrice H Lalive
Journal:  J Neuroinflammation       Date:  2022-04-29       Impact factor: 9.587

9.  Heme oxygenase and the immune system in normal and pathological pregnancies.

Authors:  Maide Ozen; Hui Zhao; David B Lewis; Ronald J Wong; David K Stevenson
Journal:  Front Pharmacol       Date:  2015-04-24       Impact factor: 5.810

10.  HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.

Authors:  Liting Yan; Xiaoxi He; Yinghua Tang; Xiaomin Zhao; Gang Luo; Xinhong Wang
Journal:  J Physiol Biochem       Date:  2021-08-07       Impact factor: 4.158
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