Literature DB >> 2547609

The genes for human alcohol dehydrogenases beta 1 and beta 2 differ by only one nucleotide.

Y Matsuo1, R Yokoyama, S Yokoyama.   

Abstract

Allelic differences at the alcohol dehydrogenase (ADH) and aldehyde dehydrogenase loci may have an important role in an individual's alcohol sensitivity. We have cloned and sequenced all nine exons of an ADH2(2) allele which codes for an 'atypical' ADH, ADH beta 2. Our sequence data shows that the histidine at residue 47 of ADH beta 2 is encoded by CAC. Surprisingly, no silent substitution was found between the coding regions of ADH2(1) [Duester, G., Smith, M., Bilanchone, V. & Hatfield, G. W. (1986) J. Biol. Chem. 261, 2027-2033.] and ADH2(2) alleles over the 1122 nucleotide sites.

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Year:  1989        PMID： 2547609     DOI： 10.1111/j.1432-1033.1989.tb14931.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  9 in total

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