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Literature DB >> 25475957

Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.

David J Vance¹, Yinghui Rong¹, Robert N Brey², Nicholas J Mantis³.

Abstract

In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Antigen; Biodefense; Toxin; Vaccine

Mesh：

Substances：

Year: 2014 PMID： 25475957 PMCID： PMC4274239 DOI： 10.1016/j.vaccine.2014.11.036

Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641

32 in total

Review 1. Anthrax lethal and edema toxins in anthrax pathogenesis.

Authors: Shihui Liu; Mahtab Moayeri; Stephen H Leppla
Journal: Trends Microbiol Date: 2014-03-27 Impact factor: 17.079

Review 2. The who, how and where of antigen presentation to B cells.

Authors: Facundo D Batista; Naomi E Harwood
Journal: Nat Rev Immunol Date: 2009-01 Impact factor: 53.106

3. A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.

Authors: Adva Mechaly; Haim Levy; Eyal Epstein; Ronit Rosenfeld; Hadar Marcus; Einat Ben-Arie; Avigdor Shafferman; Arie Ordentlich; Ohad Mazor
Journal: J Biol Chem Date: 2012-08-06 Impact factor: 5.157

4. Rapid deamidation of recombinant protective antigen when adsorbed on aluminum hydroxide gel correlates with reduced potency of vaccine.

Authors: Ajit Joseph M D'Souza; Kevin D Mar; Joanne Huang; Sumit Majumdar; Brandi M Ford; Beverly Dyas; Robert G Ulrich; Vincent J Sullivan
Journal: J Pharm Sci Date: 2012-12-14 Impact factor: 3.534

5. Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis.

Authors: Ronald B Reisler; Paul H Gibbs; Denise K Danner; Ellen F Boudreau
Journal: Vaccine Date: 2012-09-29 Impact factor: 3.641

6. Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen.

Authors: Jaimee R Compton; Patricia M Legler; Benjamin V Clingan; Mark A Olson; Charles B Millard
Journal: Proteins Date: 2011-01-05

Review 7. Advances in the development of next-generation anthrax vaccines.

Authors: Arthur M Friedlander; Stephen F Little
Journal: Vaccine Date: 2009-11-05 Impact factor: 3.641

8. Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro.

Authors: Joanne M O'Hara; Nicholas J Mantis
Journal: J Immunol Methods Date: 2013-06-15 Impact factor: 2.303

9. Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA).

Authors: Joanne M O'Hara; Jane C Kasten-Jolly; Claire E Reynolds; Nicholas J Mantis
Journal: Immunol Lett Date: 2013-11-21 Impact factor: 3.685

Review 10. Mucosal vaccines for biodefense.

Authors: N J Mantis; L A Morici; C J Roy
Journal: Curr Top Microbiol Immunol Date: 2012 Impact factor: 4.291

9 in total

1. Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies.

Authors: Cristina Herrera; Jacqueline M Tremblay; Charles B Shoemaker; Nicholas J Mantis
Journal: J Biol Chem Date: 2015-09-22 Impact factor: 5.157

2. Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication.

Authors: Jennifer L Yates; Elizabeth Leadbetter; Nicholas J Mantis
Journal: Hum Vaccin Immunother Date: 2018-05-14 Impact factor: 3.452

3. Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

Authors: Newton Wahome; Erin Sully; Christopher Singer; Justin C Thomas; Lei Hu; Sangeeta B Joshi; David B Volkin; Jianwen Fang; John Karanicolas; Donald J Jacobs; Nicholas J Mantis; C Russell Middaugh
Journal: J Pharm Sci Date: 2016-03-15 Impact factor: 3.534

Review 4. Progress and challenges associated with the development of ricin toxin subunit vaccines.

Authors: David J Vance; Nicholas J Mantis
Journal: Expert Rev Vaccines Date: 2016-04-06 Impact factor: 5.217

5. Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

Authors: David J Vance; Christopher J Greene; Yinghui Rong; Lorrie M Mandell; Terry D Connell; Nicholas J Mantis
Journal: Clin Vaccine Immunol Date: 2015-10-21

6. Evaluation of immunogenicity and protective efficacy of recombinant outer membrane proteins of Haemophilus parasuis serovar 5 in a murine model.

Authors: Miao Li; Ru-Jian Cai; Shuai Song; Zhi-Yong Jiang; Yan Li; Hong-Chao Gou; Pin-Pin Chu; Chun-Ling Li; Hua-Ji Qiu
Journal: PLoS One Date: 2017-04-27 Impact factor: 3.240