Literature DB >> 2547594

GnRH receptors in human granulosa cells: anatomical localization and characterization by autoradiographic study.

J Latouche1, M Crumeyrolle-Arias, D Jordan, N Kopp, B Augendre-Ferrante, L Cedard, F Haour.   

Abstract

The presence of receptors for GnRH in human ovary has been investigated by quantitative autoradiography. Simultaneous visualization and characterization of specific receptors on frozen sections were obtained on six pairs of human ovaries. Among them only one exhibited a large preovulatory follicle. This dominant follicle exhibited a specific and high affinity binding capacity for 125I-GnRHa exclusively localized on the granulosa cell layer. Analysis of saturation curve indicates a Kd value of 0.22 nM and Bmax of 9.6 fmol/mg protein. In contrast LH-hCG binding sites were present in all antral follicles. These data demonstrate for the first time the presence of high affinity GnRH receptors in human granulosa cells at a late stage of follicular maturation.

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Year:  1989        PMID： 2547594     DOI： 10.1210/endo-125-3-1739

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  17 in total

1.  Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty.

Authors:  B Predieri; S Luisi; E Casarosa; E Farinelli; F Antoniazzi; M Wasniewska; S Bernasconi; F Petraglia; L Iughetti
Journal:  J Endocrinol Invest       Date:  2010-06-04       Impact factor: 4.256

2.  Effects of low- and high-intensity exercise training on body composition and substrate metabolism in obese adolescents.

Authors:  S Lazzer; C Lafortuna; C Busti; R Galli; F Agosti; A Sartorio
Journal:  J Endocrinol Invest       Date:  2010-08-31       Impact factor: 4.256

3.  Association of inhibin B serum levels with parameters of follicular response in a randomized controlled trial comparing gnRH agonist versus antagonist protocols for ovarian hyperstimulation.

Authors:  Barbara Sonntag; Ludwig Kiesel; Eberhard Nieschlag; Hermann M Behre
Journal:  J Assist Reprod Genet       Date:  2004-07       Impact factor: 3.412

4.  Improvement of IVF outcome in poor responders by discontinuation of GnRH analogue during the gonadotropin stimulation phase--a function of improved embryo quality.

Authors:  M Schachter; S Friedler; A Raziel; D Strassburger; O Bern; R Ron-el
Journal:  J Assist Reprod Genet       Date:  2001-04       Impact factor: 3.412

5.  The effect of leuprorelin on steroidogenesis of human preovulatory granulosa cells in vitro.

Authors:  R Fabbri; E Porcu; A Pession; E Sereni; T Marsella; R Seracchioli; C Flamigni
Journal:  J Assist Reprod Genet       Date:  1996-04       Impact factor: 3.412

6.  Comparative analysis of the effects of gonadotropin-releasing hormone agonist on the proliferative activity, apoptosis, and steroidogenesis in cultured porcine granulosa cells at varying stages of follicular growth.

Authors:  S Takekida; J Deguchi; T Samoto; H Matsuo; T Maruo
Journal:  Endocrine       Date:  2000-02       Impact factor: 3.633

7.  Subpopulations of human granulosa-luteal cells obtained from gonadotropin- or gonadotropin-releasing hormone agonist/gonadotropin-treated follicles in in vitro fertilization-embryo transfer cycles.

Authors:  K Gersak; T Tomazevic
Journal:  J Assist Reprod Genet       Date:  1999-10       Impact factor: 3.412

8.  A comparative, randomized study of three different progesterone support of the luteal phase following IVF/ET program.

Authors:  P G Artini; A Volpe; S Angioni; M C Galassi; C Battaglia; A R Genazzani
Journal:  J Endocrinol Invest       Date:  1995-01       Impact factor: 4.256

9.  Hormone profiles under ovarian stimulation with human menopausal gonadotropin (hMG) and concomitant administration of the gonadotropin releasing hormone (GnRH)-antagonist Cetrorelix at different dosages.

Authors:  R Felberbaum; T Reissmann; W Küpker; S Al-Hasani; O Bauer; T Schill; C Zoll; C Diedrich; K Diedrich
Journal:  J Assist Reprod Genet       Date:  1996-03       Impact factor: 3.412

10.  Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters.

Authors:  K H Baumann; L Kiesel; M Kaufmann; G Bastert; B Runnebaum
Journal:  Breast Cancer Res Treat       Date:  1993       Impact factor: 4.872
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