Literature DB >> 25475107

Clinical immunology and multiplex biomarkers of human tuberculosis.

Gerhard Walzl1, Mariëlle C Haks2, Simone A Joosten2, Léanie Kleynhans1, Katharina Ronacher1, Tom H M Ottenhoff2.   

Abstract

The discovery of tuberculosis (TB) biomarkers is an important goal in current TB research, because the availability of such markers would have significant impact on TB prevention and treatment. Correlates of protection would greatly facilitate vaccine development and evaluation, whereas correlates of TB disease risk would facilitate early diagnosis and help installing early or preventive treatment. Currently, no such markers are available. This review describes several strategies that are currently being pursued to identify TB biomarkers and places these in a clinical context. The approaches discussed include both targeted and untargeted hypothesis-free strategies. Among the first are the measurements of specific biomarkers in antigen-stimulated peripheral blood, in serum or plasma, and detailed immune cell phenotyping. Among the latter are proteomic, genomic, and transcriptomic (mRNA, miRNA) approaches. Recent and promising developments are described.
Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2014        PMID： 25475107      PMCID： PMC4382732          DOI： 10.1101/cshperspect.a018515

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  74 in total

Review 1.  Toward a unified biosignature for tuberculosis.

Authors:  Jeroen Maertzdorf; Stefan H E Kaufmann; January Weiner
Journal:  Cold Spring Harb Perspect Med       Date:  2014-10-23       Impact factor: 6.915

2.  Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans.

Authors:  Güllü Topal Görgün; Gregory Whitehill; Jennifer L Anderson; Teru Hideshima; Craig Maguire; Jacob Laubach; Noopur Raje; Nikhil C Munshi; Paul G Richardson; Kenneth C Anderson
Journal:  Blood       Date:  2013-01-15       Impact factor: 22.113

3.  Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections.

Authors:  L Richeldi; M Mariani; M Losi; F Maselli; L Corbetta; C Buonsanti; M Colonna; F Sinigaglia; P Panina-Bordignon; L M Fabbri
Journal:  Eur Respir J       Date:  2004-08       Impact factor: 16.671

4.  A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus.

Authors:  Damien Chaussabel; Charles Quinn; Jing Shen; Pinakeen Patel; Casey Glaser; Nicole Baldwin; Dorothee Stichweh; Derek Blankenship; Lei Li; Indira Munagala; Lynda Bennett; Florence Allantaz; Asuncion Mejias; Monica Ardura; Ellen Kaizer; Laurence Monnet; Windy Allman; Henry Randall; Diane Johnson; Aimee Lanier; Marilynn Punaro; Knut M Wittkowski; Perrin White; Joseph Fay; Goran Klintmalm; Octavio Ramilo; A Karolina Palucka; Jacques Banchereau; Virginia Pascual
Journal:  Immunity       Date:  2008-07-18       Impact factor: 31.745

5.  An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.

Authors:  Matthew P R Berry; Christine M Graham; Finlay W McNab; Zhaohui Xu; Susannah A A Bloch; Tolu Oni; Katalin A Wilkinson; Romain Banchereau; Jason Skinner; Robert J Wilkinson; Charles Quinn; Derek Blankenship; Ranju Dhawan; John J Cush; Asuncion Mejias; Octavio Ramilo; Onn M Kon; Virginia Pascual; Jacques Banchereau; Damien Chaussabel; Anne O'Garra
Journal:  Nature       Date:  2010-08-19       Impact factor: 49.962

6.  Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.

Authors:  Novel N Chegou; Paulin N Essone; Andre G Loxton; Kim Stanley; Gillian F Black; Gian D van der Spuy; Paul D van Helden; Kees L Franken; Shreemanta K Parida; Michel R Klein; Stefan H E Kaufmann; Tom H M Ottenhoff; Gerhard Walzl
Journal:  PLoS One       Date:  2012-06-05       Impact factor: 3.240

7.  A metabolic biosignature of early response to anti-tuberculosis treatment.

Authors:  Sebabrata Mahapatra; Ann M Hess; John L Johnson; Kathleen D Eisenach; Mary A DeGroote; Phineas Gitta; Moses L Joloba; Gilla Kaplan; Gerhard Walzl; W Henry Boom; John T Belisle
Journal:  BMC Infect Dis       Date:  2014-01-31       Impact factor: 3.090

8.  Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting.

Authors:  Novel N Chegou; Anne K Detjen; Lani Thiart; Elisabetta Walters; Anna M Mandalakas; Anneke C Hesseling; Gerhard Walzl
Journal:  PLoS One       Date:  2013-05-15       Impact factor: 3.240

9.  Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers.

Authors:  Chloe I Bloom; Christine M Graham; Matthew P R Berry; Fotini Rozakeas; Paul S Redford; Yuanyuan Wang; Zhaohui Xu; Katalin A Wilkinson; Robert J Wilkinson; Yvonne Kendrick; Gilles Devouassoux; Tristan Ferry; Makoto Miyara; Diane Bouvry; Dominique Valeyre; Valeyre Dominique; Guy Gorochov; Derek Blankenship; Mitra Saadatian; Phillip Vanhems; Huw Beynon; Rama Vancheeswaran; Melissa Wickremasinghe; Damien Chaussabel; Jacques Banchereau; Virginia Pascual; Ling-Pei Ho; Marc Lipman; Anne O'Garra
Journal:  PLoS One       Date:  2013-08-05       Impact factor: 3.240

10.  Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report.

Authors:  Novel N Chegou; Gillian F Black; Martin Kidd; Paul D van Helden; Gerhard Walzl
Journal:  BMC Pulm Med       Date:  2009-05-16       Impact factor: 3.317
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  16 in total

Review 1.  [Drug-resistant tuberculosis. Epidemiology, diagnostics and therapy].

Authors:  M P Grobusch; F Schaumburg; E Altpeter; S Bélard
Journal:  Internist (Berl)       Date:  2016-02       Impact factor: 0.743

Review 2.  Toward a unified biosignature for tuberculosis.

Authors:  Jeroen Maertzdorf; Stefan H E Kaufmann; January Weiner
Journal:  Cold Spring Harb Perspect Med       Date:  2014-10-23       Impact factor: 6.915

Review 3.  Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.

Authors:  Paul K Drain; Kristina L Bajema; David Dowdy; Keertan Dheda; Kogieleum Naidoo; Samuel G Schumacher; Shuyi Ma; Erin Meermeier; David M Lewinsohn; David R Sherman
Journal:  Clin Microbiol Rev       Date:  2018-07-18       Impact factor: 26.132

4.  Design and Construction of a Eukaryotic Cloning Vector Encoding the mpt51 Gene of Mycobacterium tuberculosis.

Authors:  Faria Hasanzadeh Haghighi; Ehsan Aryan; Aida Gholoobi; Hosna Zare; Zahra Meshkat
Journal:  Rep Biochem Mol Biol       Date:  2019-04

Review 5.  Understanding immune protection against tuberculosis using RNA expression profiling.

Authors:  Ulrich von Both; Myrsini Kaforou; Michael Levin; Sandra M Newton
Journal:  Vaccine       Date:  2015-05-23       Impact factor: 3.641

6.  Circulating Angiogenic Factors as Biomarkers of Disease Severity and Bacterial Burden in Pulmonary Tuberculosis.

Authors:  Nathella Pavan Kumar; Vaithilingam V Banurekha; Dina Nair; Subash Babu
Journal:  PLoS One       Date:  2016-01-04       Impact factor: 3.240

Review 7.  Proteomics of Mycobacterium Infection: Moving towards a Better Understanding of Pathogen-Driven Immunomodulation.

Authors:  Eik Hoffmann; Arnaud Machelart; Ok-Ryul Song; Priscille Brodin
Journal:  Front Immunol       Date:  2018-01-30       Impact factor: 7.561

8.  Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients.

Authors:  Marthe Jøntvedt Jørgensen; Kristin G Nore; Hans Christian D Aass; Emilie Layre; Jérôme Nigou; Rasmus Mortensen; Kjetil Tasken; Dag Kvale; Synne Jenum; Kristian Tonby; Anne Ma Dyrhol-Riise
Journal:  Front Cell Infect Microbiol       Date:  2021-07-09       Impact factor: 5.293

9.  Host Protein Biomarkers Identify Active Tuberculosis in HIV Uninfected and Co-infected Individuals.

Authors:  Jacqueline M Achkar; Laetitia Cortes; Pascal Croteau; Corey Yanofsky; Marija Mentinova; Isabelle Rajotte; Michael Schirm; Yiyong Zhou; Ana Paula Junqueira-Kipnis; Victoria O Kasprowicz; Michelle Larsen; René Allard; Joanna Hunter; Eustache Paramithiotis
Journal:  EBioMedicine       Date:  2015-07-30       Impact factor: 8.143

Review 10.  Interleukin-10 Family and Tuberculosis: An Old Story Renewed.

Authors:  Abualgasim Elgaili Abdalla; Nzungize Lambert; Xiangke Duan; Jianping Xie
Journal:  Int J Biol Sci       Date:  2016-04-27       Impact factor: 6.580
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