J Y Kim1,2, O S Lee3, S Ha4, J H Kim5, G Park1, J K Kim6, C H Oh1,2,5. 1. Research Institute for Skin Imaging, College of Medicine, Korea University, Seoul, Korea. 2. Biomedical Engineering, Biomedical Science of Brain Korea 21, Korea Universitiy, Seoul, Korea. 3. Department of Radiological Science, College of Natural Science, Gimcheon University, Gyeongbuk, Korea. 4. Department of Nursing, School of Health, Chungbuk Health and Science University, Chungbuk, Korea. 5. Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. 6. Medical Engineering R&D Center, ASAN Medical Center, Seoul, Korea.
Abstract
BACKGROUND: Noninvasive methods of assessment are widely used in clinical trials. However, such methods have not been established in atopic dermatitis (AD), which is a chronic inflammatory skin disease. AIM: To demonstrate, using biomedical tools, the benefits of a new substance, taxifolin glycoside (TAX), in an AD model, the NC/Nga mouse. METHODS: We evaluated the efficacy of topical TAX for AD by measuring clinical skin severity score, cytokine expression and serum IgE level, and by using biomedical measures (vapometry and corneometry). Topical TAX was applied to AD-induced NC/Nga mice for 3 weeks. The anti-inflammatory effects of this compound were demonstrated noninvasively using biomedical tools and immunological assays. RESULTS: Our method of AD assessment using biomedical tools is more objective and accurate than visual inspection. The results obtained using the biomedical tools were identical to those obtained using immunological assays. CONCLUSIONS: In vivo biomedical tools are useful for diagnosing and monitoring treatment effects in AD.
BACKGROUND: Noninvasive methods of assessment are widely used in clinical trials. However, such methods have not been established in atopic dermatitis (AD), which is a chronic inflammatory skin disease. AIM: To demonstrate, using biomedical tools, the benefits of a new substance, taxifolin glycoside (TAX), in an AD model, the NC/Nga mouse. METHODS: We evaluated the efficacy of topical TAX for AD by measuring clinical skin severity score, cytokine expression and serum IgE level, and by using biomedical measures (vapometry and corneometry). Topical TAX was applied to AD-induced NC/Nga mice for 3 weeks. The anti-inflammatory effects of this compound were demonstrated noninvasively using biomedical tools and immunological assays. RESULTS: Our method of AD assessment using biomedical tools is more objective and accurate than visual inspection. The results obtained using the biomedical tools were identical to those obtained using immunological assays. CONCLUSIONS: In vivo biomedical tools are useful for diagnosing and monitoring treatment effects in AD.