OBJECTIVES: The purpose of this study was to evaluate the differences in 5-year morphological changes among the patients with combined pulmonary fibrosis and emphysema (CPFE), emphysema alone, and fibrosis alone using quantitative computed tomography evaluation. METHODS: This study involved 42 patients with CPFE, 45 patients with emphysema alone, and 35 patients with fibrosis alone who underwent computed tomography scans twice (initial and 5 years after the initial scan). The extent of emphysematous lesions was obtained by calculating the percentage of low attenuation area (%LAA) lower than -950 Hounsfield units. Fibrotic lesion was defined as a high attenuation area (HAA) using thresholds with pixels between 0 and -700 Hounsfield units, and the extent of fibrosis was obtained by calculating the mean percentage of HAA (%HAA). For the quantitative evaluation of the total area of emphysematous change and fibrosis, the percentage of destructed lung area (%DA) was obtained by summing %LAA and %HAA. The 5-year changes of %LAA, %HAA, and %DA were calculated. Differences were evaluated by 1-way analysis of variance, which was followed by the Tukey-Kramer test. RESULTS: The mean change of %LAA was significantly higher in CPFE (7.4% ± 3.8%) than in emphysema alone (P < 0.05). The mean change of %DA was significantly higher in CPFE (12.9% ± 5.8%) than in emphysema alone (4.9% ± 2.8%) and fibrosis alone (7.1% ± 5.7%). CONCLUSIONS: Morphological disease progression in CPFE differed from that in emphysema alone or fibrosis alone. In particular, the increase in emphysematous low-attenuation lesions was significantly higher in CPFE.
OBJECTIVES: The purpose of this study was to evaluate the differences in 5-year morphological changes among the patients with combined pulmonary fibrosis and emphysema (CPFE), emphysema alone, and fibrosis alone using quantitative computed tomography evaluation. METHODS: This study involved 42 patients with CPFE, 45 patients with emphysema alone, and 35 patients with fibrosis alone who underwent computed tomography scans twice (initial and 5 years after the initial scan). The extent of emphysematous lesions was obtained by calculating the percentage of low attenuation area (%LAA) lower than -950 Hounsfield units. Fibrotic lesion was defined as a high attenuation area (HAA) using thresholds with pixels between 0 and -700 Hounsfield units, and the extent of fibrosis was obtained by calculating the mean percentage of HAA (%HAA). For the quantitative evaluation of the total area of emphysematous change and fibrosis, the percentage of destructed lung area (%DA) was obtained by summing %LAA and %HAA. The 5-year changes of %LAA, %HAA, and %DA were calculated. Differences were evaluated by 1-way analysis of variance, which was followed by the Tukey-Kramer test. RESULTS: The mean change of %LAA was significantly higher in CPFE (7.4% ± 3.8%) than in emphysema alone (P < 0.05). The mean change of %DA was significantly higher in CPFE (12.9% ± 5.8%) than in emphysema alone (4.9% ± 2.8%) and fibrosis alone (7.1% ± 5.7%). CONCLUSIONS: Morphological disease progression in CPFE differed from that in emphysema alone or fibrosis alone. In particular, the increase in emphysematous low-attenuation lesions was significantly higher in CPFE.
Authors: Anna J Podolanczuk; Elizabeth C Oelsner; R Graham Barr; Eric A Hoffman; Hilary F Armstrong; John H M Austin; Robert C Basner; Matthew N Bartels; Jason D Christie; Paul L Enright; Bernadette R Gochuico; Karen Hinckley Stukovsky; Joel D Kaufman; P Hrudaya Nath; John D Newell; Scott M Palmer; Dan Rabinowitz; Ganesh Raghu; Jessica L Sell; Jered Sieren; Sushil K Sonavane; Russell P Tracy; Jubal R Watts; Kayleen Williams; Steven M Kawut; David J Lederer Journal: Eur Respir J Date: 2016-07-28 Impact factor: 16.671
Authors: Felix W Feldhaus; Dorothea Cornelia Theilig; Ralf-Harto Hubner; Jan-Martin Kuhnigk; Konrad Neumann; Felix Doellinger Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-07-17
Authors: Kum Ju Chae; Gong Yong Jin; Hyun Nyeong Jung; Keun Sang Kwon; Hyemi Choi; Yong Chul Lee; Myoung Ja Chung; Ho Sung Park Journal: PLoS One Date: 2016-09-09 Impact factor: 3.240
Authors: Hannah Fleming; Simon M Clifford; Aoife Haughey; Roisin MacDermott; Niall McVeigh; Gerard M Healy; Lisa Lavelle; Suhny Abbara; David J Murphy; Aurelie Fabre; Edward McKone; Cormac McCarthy; Marcus Butler; Peter Doran; David A Lynch; Michael P Keane; Jonathan D Dodd Journal: Eur Radiol Exp Date: 2020-11-03