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Literature DB >> 2547411

The effect of indomethacin and enalapril on the cutaneous response to bradykinin.

Abstract

The angiotensin converting enzyme inhibitors potentiate the wheal response to intradermal bradykinin. Both converting enzyme inhibitors and bradykinin stimulate prostaglandin synthesis and prostaglandins enhance the cutaneous response to bradykinin. We examined the possibility that the increased wheal response to intradermal bradykinin in the presence of enalapril was due to the effect of prostaglandins. Indomethacin did not inhibit the potentiation by enalapril of the wheal response to bradykinin.

Entities: Chemical Gene

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Year: 1989 PMID： 2547411 PMCID： PMC1379817 DOI： 10.1111/j.1365-2125.1989.tb03452.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

12 in total

1. Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.

Authors: R M Zusman; H R Keiser
Journal: J Clin Invest Date: 1977-07 Impact factor: 14.808

10. Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin.

Authors: E Vinge
Journal: Eur J Clin Pharmacol Date: 1985 Impact factor: 2.953

4 in total

1. The effect of sulindac on dermal responses to bradykinin in normal subjects given an angiotensin converting enzyme inhibitor.

Authors: R E Ferner; F Kamali; M D Rawlins
Journal: Br J Clin Pharmacol Date: 1990-03 Impact factor: 4.335

2. Effect of enalapril on allergen-induced cutaneous hypersensitivity reaction.

Authors: J R Snyman; D K Sommers
Journal: Br J Clin Pharmacol Date: 1991-12 Impact factor: 4.335

3. Cutaneous blood flow changes and weal induced by intradermal bradykinin following pretreatment with indomethacin and captopril.

Authors: T C Wa; E D Cooke; P Turner
Journal: Eur J Clin Pharmacol Date: 1993 Impact factor: 2.953

Review 4. Enalapril. A reappraisal of its pharmacology and therapeutic use in hypertension.

Authors: P A Todd; K L Goa
Journal: Drugs Date: 1992-03 Impact factor: 9.546

4 in total

The effect of indomethacin and enalapril on the cutaneous response to bradykinin.

1. Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.

2. Bradykinin induced wheal and flare is not mediated by histamine release or cyclooxygenase products.

3. Time-dependent inhibition of platelet cyclooxygenase by indomethacin is slowly reversible.

4. A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.

5. Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma.

6. Effect of enalapril on the skin response to bradykinin in man.

7. Renin- and non-renin-mediated antihypertensive actions of converting enzyme inhibitors.

8. Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man.

9. Bradykinin-induced bronchoconstriction in humans. Mode of action.

10. Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin.

1. The effect of sulindac on dermal responses to bradykinin in normal subjects given an angiotensin converting enzyme inhibitor.

2. Effect of enalapril on allergen-induced cutaneous hypersensitivity reaction.

3. Cutaneous blood flow changes and weal induced by intradermal bradykinin following pretreatment with indomethacin and captopril.

Review 4. Enalapril. A reappraisal of its pharmacology and therapeutic use in hypertension.