BACKGROUNDS/AIMS: Relationships of mean platelet volume (MPV) and thrombopoietin (TPO) with platelet turnover assessed by glycocalicin measurement were evaluated in thrombocytopenic patients. METHODS: MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPT patients. All the included ITP patients had PA-IgG ≥300% and glycocalicin ≥50% of control values, and HPT patients had PA-IgG <300% and glycocalicin <50% of control values. RESULTS AND CONCLUSIONS: MPV was higher in ITP than in HPT patients: 9.56 ± 1.69 and 7.59 ± 0.90 fl (p < 0.001). In the ITP group a direct correlation was detected between MPV and glycocalicin (r = 0.344, p < 0.001). This interaction was essentially expressed in patients with normal/increased glycocalicin (≥100% of control; r = 0.470, p < 0.001, n = 64). TPO was greatly enhanced in HPT in comparison with ITP patients (958 ± 659 and 11 ± 27 pg/ml, p < 0.001). In the ITP group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
BACKGROUNDS/AIMS: Relationships of mean platelet volume (MPV) and thrombopoietin (TPO) with platelet turnover assessed by glycocalicin measurement were evaluated in thrombocytopenicpatients. METHODS: MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPTpatients. All the included ITP patients had PA-IgG ≥300% and glycocalicin ≥50% of control values, and HPTpatients had PA-IgG <300% and glycocalicin <50% of control values. RESULTS AND CONCLUSIONS: MPV was higher in ITP than in HPTpatients: 9.56 ± 1.69 and 7.59 ± 0.90 fl (p < 0.001). In the ITP group a direct correlation was detected between MPV and glycocalicin (r = 0.344, p < 0.001). This interaction was essentially expressed in patients with normal/increased glycocalicin (≥100% of control; r = 0.470, p < 0.001, n = 64). TPO was greatly enhanced in HPT in comparison with ITP patients (958 ± 659 and 11 ± 27 pg/ml, p < 0.001). In the ITP group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
Authors: Anastasia A Ignatova; Elena V Suntsova; Alexey V Pshonkin; Alexey A Martyanov; Evgeniya A Ponomarenko; Dmitry M Polokhov; Daria V Fedorova; Kirill A Voronin; Natalia N Kotskaya; Natalia M Trubina; Marina V Krasilnikova; Selima Sh Uzueva; Irina V Serkova; Galina S Ovsyannikova; Ksenia I Romanova; Lili A Hachatryan; Irina I Kalinina; Viktor E Matveev; Maya N Korsantiya; Natalia S Smetanina; Dmitry A Evseev; Maria N Sadovskaya; Kristina S Antonova; Anna L Khoreva; Pavel A Zharkov; Anna Shcherbina; Anastasia N Sveshnikova; Aleksey A Maschan; Galina A Novichkova; Mikhail A Panteleev Journal: Sci Rep Date: 2021-04-30 Impact factor: 4.379