Literature DB >> 25472627

A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound.

Hsin-Yang Huang1, Hao-Li Liu, Po-Hung Hsu, Chih-Sheng Chiang, Chih-Hung Tsai, Huei-Shang Chi, San-Yuan Chen, You-Yin Chen.   

Abstract

A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  brain-blood barrier; focused ultrasound; magnetic guidance; nanobubbles

Mesh：

Substances：

Year:  2014        PMID： 25472627     DOI： 10.1002/adma.201403889

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  24 in total

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