Literature DB >> 2547146

Gangliosides in SV-40-transformed cells derived from Tay-Sachs disease fetal brain.

L M Hoffman1, S E Brooks, M R Stein, M Adachi, L Schneck.   

Abstract

A human glial brain cell line derived from a Tay-Sachs disease fetal cerebellum was transformed with SV-40 virus in order to obtain a transformed brain cell line which reflected the characteristics of the disease. It was shown that the transformed TSD cell line maintained an elevated level of GM2 which was similar to that shown by the nontransformed precursor. In addition, the TSD transformed line lacked hexosaminidase A.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2547146     DOI： 10.1007/BF00999386

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  24 in total

1.  Glycosphingolipids in fetal Tay-Sachs disease brain and lung cultures.

Authors:  L M Hoffman; D Amsterdam; S E Brooks; L Schneck
Journal:  J Neurochem       Date:  1977-09       Impact factor: 5.372

2.  Human fetal brain cells in culture. Increase in GM2 ganglioside after SV-40 transformation.

Authors:  L M Hoffman; S E Brooks; L Schneck
Journal:  Biochim Biophys Acta       Date:  1981-09-24

3.  GM2 ganglioside in fetal Tay-Sachs disease brain cultures: a model system for the disease.

Authors:  L M Hoffman; D Amsterdam; L Schneck
Journal:  Brain Res       Date:  1976-07-23       Impact factor: 3.252

4.  A murine monoclonal antibody detecting N-acetyl- and N-glycolyl-GM2: characterization of cell surface reactivity.

Authors:  E J Natoli; P O Livingston; C S Pukel; K O Lloyd; H Wiegandt; J Szalay; H F Oettgen; L J Old
Journal:  Cancer Res       Date:  1986-08       Impact factor: 12.701

5.  Enzyme replacement treatment for Tay-Sachs disease brain cells in culture utilizing concanavalin A-mediated hexosaminidase A uptake: biochemical and morphological evidence of GM2 mobilization.

Authors:  S E Brooks; L M Hoffman; M Adachi; D Amsterdam; L Schneck
Journal:  Acta Neuropathol       Date:  1980       Impact factor: 17.088

6.  An assessment of methanolysis and other factors used in the analysis of carbohydrate-containing materials.

Authors:  R E Chambers; J R Clamp
Journal:  Biochem J       Date:  1971-12       Impact factor: 3.857

7.  Tay-Sachs disease and normal cerebellar cells in culture: elevated levels of lysosomal enzymes in Tay-Sachs disease cells.

Authors:  L M Hoffman; S E Brooks; L Schneck
Journal:  J Neurosci Res       Date:  1982       Impact factor: 4.164

8.  Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects.

Authors:  S Sonderfeld; E Conzelmann; G Schwarzmann; J Burg; U Hinrichs; K Sandhoff
Journal:  Eur J Biochem       Date:  1985-06-03

9.  GM2-ganglioside metabolism in cultured human skin fibroblasts: unambiguous diagnosis of GM2-gangliosidosis.

Authors:  S Raghavan; A Krusell; T A Lyerla; E G Bremer; E H Kolodny
Journal:  Biochim Biophys Acta       Date:  1985-04-25

10.  Molecular forms of beta-N-acetylhexosaminidase in Epstein-Barr virus-transformed lymphoid cell lines from normal subjects and patients with Tay-Sachs disease.

Authors:  R Salvayre; A Maret; A Negre; G Lenoir; M Vuillaume; J Icart; J Didier; L Douste-Blazy
Journal:  Eur J Biochem       Date:  1983-07-01
View more
  1 in total

1.  Ganglioside biosynthesis in developing brains and apoptotic cancer cells: X. regulation of glyco-genes involved in GD3 and Sialyl-Lex/a syntheses.

Authors:  Subhash Basu; Rui Ma; Joseph R Moskal; Manju Basu
Journal:  Neurochem Res       Date:  2012-04-10       Impact factor: 3.996
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.