Disruption of circadian blood pressure, heart rate and the impact on glycemic control in type 1 diabetes.

Patients with type 1 diabetes (DM-1) have an increased mortality and morbidity risk compared to non-diabetic subjects. Even not recognized clinically at the early period of disease; patients with DM-1 show subtle neurological and cardiovascular abnormalities which is partly responsible for the increased mortality. One of these abnormalities is the disruption of circadian rhythms. Various factors such as autonomic dysfunction, sleep disturbance, smoking, cardiac and kidney function, atherosclerosis, arterial stiffness are suggested to cause these disturbances. Additionally these abnormalities have also implications regarding target organ damage such as microalbuminuria, retinopathy, and structural changes in glomeruli. Surprisingly, there are scarce data regarding the effect of tight blood glucose control and insulin on circadian rhythms in patients with DM-1. By the light of aforementioned data this review will try to summarize causes and consequences of disruption of circadian rhythms and the impact on glycemic control on these issues in patients with DM-1.