Expanding the brain glucosensing territory.

Brain glucosensing neurons monitor extracellular glucose concentrations and act to defend normoglycemia. To date, the majority of these neurons have been ascribed to hypothalamic and hindbrain centers. In this issue, Garfield and colleagues (2014) demonstrate that cholecystokinin-expressing neurons in the rodent parabrachial nucleus function as glucosensors that counter-regulate hypoglycemia.