Literature DB >> 25470542

Betatrophin--promises fading and lessons learned.

Klaus H Kaestner1.   

Abstract

The discovery of a potent mitogen for insulin-producing pancreatic β cells, optimistically termed "betatrophin," excited researchers and laypeople alike, promising a new therapeutic approach to diabetes. A recent "Matters Arising" report by Gusarova and colleagues (2014) places serious doubts on whether "betatrophin" plays any major role in β cell replication.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25470542      PMCID： PMC4410809          DOI： 10.1016/j.cmet.2014.11.016

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  11 in total

1.  Perspectives on the activities of ANGPTL8/betatrophin.

Authors:  Peng Yi; Ji-Sun Park; Douglas A Melton
Journal:  Cell       Date:  2014-10-23       Impact factor: 41.582

2.  Evidence for a circulating islet cell growth factor in insulin-resistant states.

Authors:  S N Flier; R N Kulkarni; C R Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-12       Impact factor: 11.205

3.  Betatrophin: a hormone that controls pancreatic β cell proliferation.

Authors:  Peng Yi; Ji-Sun Park; Douglas A Melton
Journal:  Cell       Date:  2013-04-25       Impact factor: 41.582

4.  Disruption of IRS-2 causes type 2 diabetes in mice.

Authors:  D J Withers; J S Gutierrez; H Towery; D J Burks; J M Ren; S Previs; Y Zhang; D Bernal; S Pons; G I Shulman; S Bonner-Weir; M F White
Journal:  Nature       Date:  1998-02-26       Impact factor: 49.962

5.  Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Authors:  M D Michael; R N Kulkarni; C Postic; S F Previs; G I Shulman; M A Magnuson; C R Kahn
Journal:  Mol Cell       Date:  2000-07       Impact factor: 17.970

6.  Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication.

Authors:  Dana Avrahami; Changhong Li; Ming Yu; Yang Jiao; Jia Zhang; Ali Naji; Seyed Ziaie; Benjamin Glaser; Klaus H Kaestner
Journal:  J Clin Invest       Date:  2014-01-16       Impact factor: 14.808

7.  Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis.

Authors:  Yan Wang; Fabiana Quagliarini; Viktoria Gusarova; Jesper Gromada; David M Valenzuela; Jonathan C Cohen; Helen H Hobbs
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

8.  Partial pancreatectomy in adult humans does not provoke beta-cell regeneration.

Authors:  Bjoern A Menge; Andrea Tannapfel; Orlin Belyaev; Robert Drescher; Christophe Müller; Waldemar Uhl; Wolfgang E Schmidt; Juris J Meier
Journal:  Diabetes       Date:  2007-10-24       Impact factor: 9.461

9.  A novel high-affinity peptide antagonist to the insulin receptor.

Authors:  Lauge Schäffer; Christian L Brand; Bo F Hansen; Ulla Ribel; Allan C Shaw; Rita Slaaby; Jeppe Sturis
Journal:  Biochem Biophys Res Commun       Date:  2008-09-07       Impact factor: 3.575

10.  Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting.

Authors:  Yang Jiao; John Le Lay; Ming Yu; Ali Naji; Klaus H Kaestner
Journal:  Diabetes       Date:  2013-12-18       Impact factor: 9.461
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  5 in total

1.  Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis.

Authors:  Sheyu Li; Dan Liu; Ling Li; Yun Li; Qianrui Li; Zhenmei An; Xin Sun; Haoming Tian
Journal:  J Diabetes Res       Date:  2015-12-01       Impact factor: 4.011

2.  Increased circulating full-length betatrophin levels in drug-naïve metabolic syndrome.

Authors:  Dan Liu; Sheyu Li; He He; Chuan Yu; Xiaodan Li; Libo Liang; Yi Chen; Jianwei Li; Jianshu Li; Xin Sun; Haoming Tian; Zhenmei An
Journal:  Oncotarget       Date:  2017-03-14

Review 3.  Newly discovered endocrine functions of the liver.

Authors:  Jane Rhyu; Run Yu
Journal:  World J Hepatol       Date:  2021-11-27

4.  Regulation of Lipid Metabolism and Beyond.

Authors:  Youngah Jo; Hiroaki Okazaki; Young-Ah Moon; TongJin Zhao
Journal:  Int J Endocrinol       Date:  2016-05-12       Impact factor: 3.257

5.  Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol.

Authors:  Min Yi; Rong-Ping Chen; Rui Yang; Xian-Feng Guo; Jia-Chun Zhang; Hong Chen
Journal:  Int J Endocrinol       Date:  2015-12-24       Impact factor: 3.257
  5 in total

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