Literature DB >> 25470335

Direct transfection of dendritic cells in the epidermis after plasmid delivery enhanced by surface electroporation.

Dinah H Amante1, Trevor R F Smith, Bill B Kiosses, Niranjan Y Sardesai, Laurent M P F Humeau, Kate E Broderick.   

Abstract

The skin is rich in antigen-presenting cells and as such is an excellent target tissue for vaccination strategies. Electroporation is a physical delivery method that potentiates the uptake of DNA vaccines into target cells. Intradermal electroporation offers a minimally invasive solution to DNA delivery in the clinic. Here we describe the direct transfection of dendritic cells in the epidermis, using a surface dermal electroporation device, and specifically show a dendritic cell transfected with plasmid expressing green fluorescent protein. The dendritic cell has used its motile capabilities after transfection to move from the epidermis into the dermis, making its way to the lymphatic system.

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Year:  2014        PMID： 25470335      PMCID： PMC4268584          DOI： 10.1089/hgtb.2014.061

Source DB:  PubMed          Journal:  Hum Gene Ther Methods        ISSN： 1946-6536            Impact factor:   2.396


  5 in total

1.  Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device.

Authors:  K E Broderick; X Shen; J Soderholm; F Lin; J McCoy; A S Khan; J Yan; M P Morrow; A Patel; G P Kobinger; S Kemmerrer; D B Weiner; N Y Sardesai
Journal:  Gene Ther       Date:  2010-10-21       Impact factor: 5.250

Review 2.  The immunobiology of muscle.

Authors:  R Hohlfeld; A G Engel
Journal:  Immunol Today       Date:  1994-06

Review 3.  Electroporation delivery of DNA vaccines: prospects for success.

Authors:  Niranjan Y Sardesai; David B Weiner
Journal:  Curr Opin Immunol       Date:  2011-04-27       Impact factor: 7.486

4.  DNA vaccines: crossing a line in the sand. Introduction to special issue.

Authors:  David B Weiner
Journal:  Vaccine       Date:  2008-07-22       Impact factor: 3.641

5.  Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation.

Authors:  Janess M Mendoza; Dinah H Amante; Gleb Kichaev; Christine L Knott; William B Kiosses; Trevor R F Smith; Niranjan Y Sardesai; Kate E Broderick
Journal:  Vaccines (Basel)       Date:  2013-08-28
  5 in total
  5 in total

1.  A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever.

Authors:  Kathleen A Cashman; Eric R Wilkinson; Carl I Shaia; Paul R Facemire; Todd M Bell; Jeremy J Bearss; Joshua D Shamblin; Suzanne E Wollen; Kate E Broderick; Niranjan Y Sardesai; Connie S Schmaljohn
Journal:  Hum Vaccin Immunother       Date:  2017-10-18       Impact factor: 3.452

2.  An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice.

Authors:  Callie E Bounds; Frances E Terry; Leonard Moise; Drew Hannaman; William D Martin; Anne S De Groot; John J Suschak; Lesley C Dupuy; Connie S Schmaljohn
Journal:  Hum Vaccin Immunother       Date:  2017-06-02       Impact factor: 3.452

3.  Pre-clinical investigation of the synergy effect of interleukin-12 gene-electro-transfer during partially irreversible electropermeabilization against melanoma.

Authors:  Lise Pasquet; Elisabeth Bellard; Sophie Chabot; Bostjan Markelc; Marie-Pierre Rols; Justin Teissie; Muriel Golzio
Journal:  J Immunother Cancer       Date:  2019-06-26       Impact factor: 13.751

4.  Safe and efficient novel approach for non-invasive gene electrotransfer to skin.

Authors:  Lise Pasquet; Sophie Chabot; Elisabeth Bellard; Bostjan Markelc; Marie-Pierre Rols; Jean-Paul Reynes; Gérard Tiraby; Franck Couillaud; Justin Teissie; Muriel Golzio
Journal:  Sci Rep       Date:  2018-11-15       Impact factor: 4.379

5.  One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model.

Authors:  Karen E Gooch; Trevor R F Smith; Francisco J Salguero; Susan A Fotheringham; Robert J Watson; Mike J Dennis; Alastair Handley; Holly E Humphries; Stephanie Longet; Tom Tipton; Charlotte Sarfas; Laura Sibley; Gillian S Slack; Emma Rayner; Kathryn A Ryan; Katherine Schultheis; Stephanie J Ramos; Andrew White; Sue Charlton; Sally A Sharpe; Fergus Gleeson; Laurent M Humeau; Yper Hall; Kate E Broderick; Miles W Carroll
Journal:  Vaccine       Date:  2021-06-23       Impact factor: 4.169
  5 in total

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