Literature DB >> 25470190

The clinical pharmacology of traditional antiepileptic drugs.

Frank J E Vajda1, Mervyn J Eadie2.   

Abstract

Despite the availability of newer agents, a number of antiepileptic drugs have continued to be employed reasonably widely, many years after their introduction to human therapeutics. These drugs comprise phenobarbitone and some of its congeners, phenytoin, ethosuximide, carbamazepine, valproate, and certain benzodiazepines. Details of their pharmacological profiles are outlined in the following account.

Entities:  

Keywords:  benzodiazepines; carbamazepine; ethosuximide; mechanism of action; pharmacokinetics; phenobarbitone; phenytoin; valproate

Mesh：

Substances：

Year:  2014        PMID： 25470190     DOI： 10.1684/epd.2014.0704

Source DB:  PubMed          Journal:  Epileptic Disord        ISSN： 1294-9361            Impact factor:   1.819


  12 in total

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Authors:  Clare E Stevens; Carl E Stafstrom
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2.  Allosteric modulation of sigma-1 receptors elicits anti-seizure activities.

Authors:  Lin Guo; Yanke Chen; Rui Zhao; Guanghui Wang; Eitan Friedman; Ao Zhang; Xuechu Zhen
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3.  Prenatal exposure to valproic acid alters Reelin, NGF expressing neuron architecture and impairs social interaction in their autistic-like phenotype male offspring.

Authors:  Karunanithi Sivasangari; Koilmani Emmanuvel Rajan
Journal:  Exp Brain Res       Date:  2022-06-01       Impact factor: 2.064

4.  Long-term treatment of epilepsy with everolimus in tuberous sclerosis.

Authors:  Darcy A Krueger; Angus A Wilfong; Maxwell Mays; Christina M Talley; Karen Agricola; Cindy Tudor; Jamie Capal; Katherine Holland-Bouley; David Neal Franz
Journal:  Neurology       Date:  2016-11-04       Impact factor: 9.910

5.  Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis.

Authors:  Hiroo Nakashima; Kentaro Oniki; Miki Nishimura; Naoki Ogusu; Masatsugu Shimomasuda; Tatsumasa Ono; Kazuki Matsuda; Norio Yasui-Furukori; Kazuko Nakagawa; Takateru Ishitsu; Junji Saruwatari
Journal:  PLoS One       Date:  2015-10-20       Impact factor: 3.240

6.  Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model - Phenytoin and Valproate, Lamotrigine and Valproate.

Authors:  Kim Det Taing; Terence J O'Brien; David A Williams; Chris R French
Journal:  PLoS One       Date:  2017-01-11       Impact factor: 3.240

7.  The Cyclic Vomiting Syndrome Threshold: A Framework for Understanding Pathogenesis and Predicting Successful Treatments.

Authors:  David J Levinthal
Journal:  Clin Transl Gastroenterol       Date:  2016-10-27       Impact factor: 4.488

8.  Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165.

Authors:  Takahiro Ohta; Mitsuo Mita; Shigeru Hishinuma; Reiko Ishii-Nozawa; Kazuhisa Takahashi; Masaru Shoji
Journal:  Front Endocrinol (Lausanne)       Date:  2017-04-28       Impact factor: 5.555

9.  Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region.

Authors:  Takahiro Mukai; Masato Kinboshi; Yuki Nagao; Saki Shimizu; Asuka Ono; Yoshihisa Sakagami; Aoi Okuda; Megumi Fujimoto; Hidefumi Ito; Akio Ikeda; Yukihiro Ohno
Journal:  Front Pharmacol       Date:  2018-08-06       Impact factor: 5.810

10.  An Epileptic Patient with Recurrent Hyperbilirubinemia Caused by Gilbert Syndrome.

Authors:  Yaoyao Zhang; Yongli Jiang; Fang Yuan; Changgeng Song; Zhihan Zhao; Wen Jiang
Journal:  Case Rep Gastroenterol       Date:  2020-01-22
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